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Period circadian protein

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Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

Below are the list of possible Period circadian protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Period circadian protein

 Period circadian protein ELISA Kit
 Period circadian protein Recombinant
 Period circadian protein Antibody
Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nerv
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ous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition ().
 per ELISA Kit
 per Recombinant
 per Antibody
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Period circadian protein homolog 1

 Period circadian protein homolog 1 ELISA Kit
 Period circadian protein homolog 1 Recombinant
 Period circadian protein homolog 1 Antibody
Also known as Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui).
PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription
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factor

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm

Molecular Function: chromatin DNA binding; kinase binding; ubiquitin protein ligase binding

Biological Process: circadian regulation of gene expression; circadian rhythm; entrainment of circadian clock; entrainment of circadian clock by photoperiod; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of hair cycle; regulation of sodium ion transport
 PER1 ELISA Kit
 PER1 Recombinant
 PER1 Antibody
 KIAA0482 ELISA Kit
 KIAA0482 Recombinant
 KIAA0482 Antibody
 PER ELISA Kit
 PER Recombinant
 PER Antibody
 RIGUI ELISA Kit
 RIGUI Recombinant
 RIGUI Antibody
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Period circadian protein homolog 2

 Period circadian protein homolog 2 ELISA Kit
 Period circadian protein homolog 2 Recombinant
 Period circadian protein homolog 2 Antibody
Also known as Period circadian protein homolog 2 (cPER2) (Circadian clock protein PERIOD 2).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene i
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s upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Feb 2014]
 PER2 ELISA Kit
 PER2 Recombinant
 PER2 Antibody
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Period circadian protein homolog 3

 Period circadian protein homolog 3 ELISA Kit
 Period circadian protein homolog 3 Recombinant
 Period circadian protein homolog 3 Antibody
Also known as Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3).
PER3: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human O
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rtholog: 1p36.23

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of circadian sleep/wake cycle, sleep

Disease: Advanced Sleep Phase Syndrome, Familial, 3
 PER3 ELISA Kit
 PER3 Recombinant
 PER3 Antibody
 GIG13 ELISA Kit
 GIG13 Recombinant
 GIG13 Antibody
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