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Peroxisome proliferator-activated receptor gamma coactivator

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Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).

Below are the list of possible Peroxisome proliferator-activated receptor gamma coactivator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ELISA Kit
 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Recombinant
 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Antibody
Also known as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha).
PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of
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mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
 Ppargc1a ELISA Kit
 Ppargc1a Recombinant
 Ppargc1a Antibody
 Pgc1 ELISA Kit
 Pgc1 Recombinant
 Pgc1 Antibody
 Pgc1a ELISA Kit
 Pgc1a Recombinant
 Pgc1a Antibody
 Ppargc1 ELISA Kit
 Ppargc1 Recombinant
 Ppargc1 Antibody
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Peroxisome proliferator-activated receptor gamma coactivator 1-beta

 Peroxisome proliferator-activated receptor gamma coactivator 1-beta ELISA Kit
 Peroxisome proliferator-activated receptor gamma coactivator 1-beta Recombinant
 Peroxisome proliferator-activated receptor gamma coactivator 1-beta Antibody
Also known as Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta).
PGC-1 beta: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of t
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he pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: nucleus; Srb-mediator complex

Molecular Function: AF-2 domain binding; estrogen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; receptor activator activity; transcription factor binding

Biological Process: actin filament organization; estrogen receptor signaling pathway; negative regulation of transcription, DNA-dependent; ossification; positive regulation of bone resorption; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to cAMP; response to glucocorticoid stimulus; transcription from mitochondrial promoter
 Ppargc1b ELISA Kit
 Ppargc1b Recombinant
 Ppargc1b Antibody
 Perc ELISA Kit
 Perc Recombinant
 Perc Antibody
 Pgc1 ELISA Kit
 Pgc1 Recombinant
 Pgc1 Antibody
 Pgc1b ELISA Kit
 Pgc1b Recombinant
 Pgc1b Antibody
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