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PH domain leucine-rich repeat-containing protein phosphatase

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Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (By similarity). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation .

Below are the list of possible PH domain leucine-rich repeat-containing protein phosphatase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PH domain leucine-rich repeat-containing protein phosphatase 1

 PH domain leucine-rich repeat-containing protein phosphatase 1 ELISA Kit
 PH domain leucine-rich repeat-containing protein phosphatase 1 Recombinant
 PH domain leucine-rich repeat-containing protein phosphatase 1 Antibody
Also known as PH domain leucine-rich repeat-containing protein phosphatase 1 (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein).
PHLPP: a pleckstrin homology domain leucine-rich repeat protein phosphoserine and ¿threonine phosphatase. A tumor suppressor that controls the onset and progression of various cancers because it controls the balance between cell survival and apoptosis. Catalyzes the dephosphorylation of the hydrophobic motif on the AGC kinases Akt, PKC, and S6 kinase, and
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the inhibitory site on the kinase Mst1. The dephosphorylation of PKCA and PKCB is destabilizing, leading to its degradation. The dephosphorylation of p70S6K at T390 reduces its activity, thus reducing the efficiency of protein translation. Dephosphorylation of Mst1 by PHLPP of an autoinhibitory site (T387) activates Mst1, resulting in the activation of the pro-apoptotic MAPK pathway. Ubiquitously expressed in non-cancerous tissues. Insensitive to inhibition by okadaic acid. PHLPP loss occurs at high frequency in colorectal cancer, and leads to the development of prostate tumors in mice. PHLPP degradation by the 26 S proteasome is controlled by a beta-TrCP-containing Skp¿Cullin 1¿F-box protein (SCF) complex E3 ubiquitin ligase in a phosphorylation-dependent manner. This degradation requires phosphorylation of PHLPP1 by CK I and GSK-3beta. Activation of the PI3K/Akt pathway suppresses the degradation of PHLPP1 by inhibiting GSK-3beta activity. PHLPP2 activity is highly sensitive to a common polymorphism (L-1016-S) that reduces its rate of dephosphorylation of the hydrophobic motif of Akt and PKC, rendering it ineffective at inducing apoptosis. This variant is expressed by 30% of the human population. Interacts with the nucleotide free form of KRas via its LRR repeats. Interacts with AKT2, AKT3 and PKCB isoform beta-II.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor

Cellular Component: cytoplasm; nuclear membrane; nucleoplasm

Molecular Function: protein serine/threonine phosphatase activity

Biological Process: entrainment of circadian clock; negative regulation of protein kinase B signaling cascade; protein amino acid dephosphorylation; regulation of apoptosis; regulation of JNK cascade; regulation of MAPKKK cascade; regulation of protein amino acid phosphorylation; regulation of T cell anergy
 Phlpp1 ELISA Kit
 Phlpp1 Recombinant
 Phlpp1 Antibody
 Kiaa0606 ELISA Kit
 Kiaa0606 Recombinant
 Kiaa0606 Antibody
 Phlpp ELISA Kit
 Phlpp Recombinant
 Phlpp Antibody
 Plekhe1 ELISA Kit
 Plekhe1 Recombinant
 Plekhe1 Antibody
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PH domain leucine-rich repeat-containing protein phosphatase 2

 PH domain leucine-rich repeat-containing protein phosphatase 2 ELISA Kit
 PH domain leucine-rich repeat-containing protein phosphatase 2 Recombinant
 PH domain leucine-rich repeat-containing protein phosphatase 2 Antibody
Also known as PH domain leucine-rich repeat-containing protein phosphatase 2 (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like).
PHLPP2: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily
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alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor

Cellular Component: cytoplasm; photoreceptor inner segment

Molecular Function: protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation
 Phlpp2 ELISA Kit
 Phlpp2 Recombinant
 Phlpp2 Antibody
 Phlppl ELISA Kit
 Phlppl Recombinant
 Phlppl Antibody
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