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Phorbol-12-myristate-13-acetate-induced protein

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Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Below are the list of possible Phorbol-12-myristate-13-acetate-induced protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phorbol-12-myristate-13-acetate-induced protein 1

 Phorbol-12-myristate-13-acetate-induced protein 1 ELISA Kit
 Phorbol-12-myristate-13-acetate-induced protein 1 Recombinant
 Phorbol-12-myristate-13-acetate-induced protein 1 Antibody
Also known as Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa).
NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation
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of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 18q21.32

Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: protein binding

Biological Process: apoptosis; cellular response to glucose starvation; defense response to virus; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein oligomerization; proteasomal protein catabolic process; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of apoptosis; regulation of mitochondrial membrane permeability; response to dsRNA; T cell homeostasis
 PMAIP1 ELISA Kit
 PMAIP1 Recombinant
 PMAIP1 Antibody
 NOXA ELISA Kit
 NOXA Recombinant
 NOXA Antibody
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