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Phosphatidylcholine translocator

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Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts .

Below are the list of possible Phosphatidylcholine translocator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylcholine translocator ABCB4

 Phosphatidylcholine translocator ABCB4 ELISA Kit
 Phosphatidylcholine translocator ABCB4 Recombinant
 Phosphatidylcholine translocator ABCB4 Antibody
Also known as Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 2) (Multidrug resistance protein 3) (P-glycoprotein 2) (P-glycoprotein 3).
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic
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cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.

Protein type: EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Cellular Component: apical plasma membrane; cytoplasm; Golgi membrane; integral to membrane; intercellular canaliculus; membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; phosphatidylcholine transmembrane transporter activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; bile acid secretion; lipid homeostasis; multidrug transport; phospholipid translocation; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cholesterol transport
 Abcb4 ELISA Kit
 Abcb4 Recombinant
 Abcb4 Antibody
 Mdr2 ELISA Kit
 Mdr2 Recombinant
 Mdr2 Antibody
 Pgy-2 ELISA Kit
 Pgy-2 Recombinant
 Pgy-2 Antibody
 Pgy2 ELISA Kit
 Pgy2 Recombinant
 Pgy2 Antibody
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