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Phosphatidylcholine:ceramide cholinephosphotransferase

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Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Below are the list of possible Phosphatidylcholine:ceramide cholinephosphotransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylcholine:ceramide cholinephosphotransferase 1

 Phosphatidylcholine:ceramide cholinephosphotransferase 1 ELISA Kit
 Phosphatidylcholine:ceramide cholinephosphotransferase 1 Recombinant
 Phosphatidylcholine:ceramide cholinephosphotransferase 1 Antibody
Also known as Phosphatidylcholine:ceramide cholinephosphotransferase 1 (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23).
TMEM23: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the cho
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line-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Belongs to the sphingomyelin synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.8.27; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: endoplasmic reticulum; Golgi membrane; Golgi trans cisterna; integral to endoplasmic reticulum membrane; integral to Golgi membrane; integral to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: ceramide cholinephosphotransferase activity; sphingomyelin synthase activity

Biological Process: cell growth; ceramide biosynthetic process; sphingolipid biosynthetic process; sphingomyelin biosynthetic process
 SGMS1 ELISA Kit
 SGMS1 Recombinant
 SGMS1 Antibody
 MOB ELISA Kit
 MOB Recombinant
 MOB Antibody
 SMS1 ELISA Kit
 SMS1 Recombinant
 SMS1 Antibody
 TMEM23 ELISA Kit
 TMEM23 Recombinant
 TMEM23 Antibody
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Phosphatidylcholine:ceramide cholinephosphotransferase 2

 Phosphatidylcholine:ceramide cholinephosphotransferase 2 ELISA Kit
 Phosphatidylcholine:ceramide cholinephosphotransferase 2 Recombinant
 Phosphatidylcholine:ceramide cholinephosphotransferase 2 Antibody
Also known as Phosphatidylcholine:ceramide cholinephosphotransferase 2 (Sphingomyelin synthase 2).
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.
 sms-2 ELISA Kit
 sms-2 Recombinant
 sms-2 Antibody
 F53H8.4 ELISA Kit
 F53H8.4 Recombinant
 F53H8.4 Antibody
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Phosphatidylcholine:ceramide cholinephosphotransferase 3

 Phosphatidylcholine:ceramide cholinephosphotransferase 3 ELISA Kit
 Phosphatidylcholine:ceramide cholinephosphotransferase 3 Recombinant
 Phosphatidylcholine:ceramide cholinephosphotransferase 3 Antibody
Also known as Phosphatidylcholine:ceramide cholinephosphotransferase 3 (Ethanolamine-phosphorylceramide synthase) (EPC synthase) (Sphingolipid synthase) (Sphingomyelin synthase) (SM synthase).
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relat
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ive concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target ().
 SLS3 ELISA Kit
 SLS3 Recombinant
 SLS3 Antibody
 Tb09.211.1010 ELISA Kit
 Tb09.211.1010 Recombinant
 Tb09.211.1010 Antibody
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Phosphatidylcholine:ceramide cholinephosphotransferase 4

 Phosphatidylcholine:ceramide cholinephosphotransferase 4 ELISA Kit
 Phosphatidylcholine:ceramide cholinephosphotransferase 4 Recombinant
 Phosphatidylcholine:ceramide cholinephosphotransferase 4 Antibody
Also known as Phosphatidylcholine:ceramide cholinephosphotransferase 4 (Ethanolamine-phosphorylceramide synthase) (EPC synthase) (Sphingolipid synthase) (Sphingomyelin synthase) (SM synthase).
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relat
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ive concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target ().
 SLS4 ELISA Kit
 SLS4 Recombinant
 SLS4 Antibody
 Tb09.211.1000 ELISA Kit
 Tb09.211.1000 Recombinant
 Tb09.211.1000 Antibody
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