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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

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Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Below are the list of possible Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 ELISA Kit
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Recombinant
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Antibody
Also known as Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship).
SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first
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recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.

Protein type: EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid

Cellular Component: actin filament; cortical cytoskeleton; cytosol; plasma membrane

Molecular Function: inositol-4,5-bisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; protein binding; PTB domain binding; SH3 domain binding

Biological Process: determination of adult life span; immunoglobulin mediated immune response; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; positive regulation of apoptosis; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of lymphocyte differentiation
 Inpp5d ELISA Kit
 Inpp5d Recombinant
 Inpp5d Antibody
 7a33 ELISA Kit
 7a33 Recombinant
 7a33 Antibody
 Ship ELISA Kit
 Ship Recombinant
 Ship Antibody
 Ship1 ELISA Kit
 Ship1 Recombinant
 Ship1 Antibody
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 ELISA Kit
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Recombinant
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Antibody
Also known as Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (AblSH3-binding protein) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2).
SHIP-2: an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R.

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Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid

Cellular Component: cytoplasm; Golgi apparatus; lamellipodium; plasma membrane

Molecular Function: inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; SH2 domain binding

Biological Process: actin filament organization; cellular lipid metabolic process; endochondral ossification; endocytosis; glucose metabolic process; inositol trisphosphate metabolic process; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of MAP kinase activity; phosphatidylinositol biosynthetic process; post-embryonic development; response to insulin stimulus
 Inppl1 ELISA Kit
 Inppl1 Recombinant
 Inppl1 Antibody
 Ship2 ELISA Kit
 Ship2 Recombinant
 Ship2 Antibody
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A

 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A ELISA Kit
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A Recombinant
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A Antibody
Also known as Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A (Inositol polyphosphate phosphatase-like protein 1A) (INPPL1-A) (SH2 domain-containing inositol 5'-phosphatase 2A) (SH2 domain-containing inositol phosphatase 2A) (SHIP-2A).
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecu
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lar mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 ().
 inppl1a ELISA Kit
 inppl1a Recombinant
 inppl1a Antibody
 ship2a ELISA Kit
 ship2a Recombinant
 ship2a Antibody
 wu:fc58a04 ELISA Kit
 wu:fc58a04 Recombinant
 wu:fc58a04 Antibody
 zgc:198309 ELISA Kit
 zgc:198309 Recombinant
 zgc:198309 Antibody
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B

 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B ELISA Kit
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B Recombinant
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B Antibody
Also known as Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B (Inositol polyphosphate phosphatase-like protein 1B) (INPPL-1B) (SH2 domain-containing inositol 5'-phosphatase 2B) (SH2 domain-containing inositol phosphatase 2B) (SHIP-2B).
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecu
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lar mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 ().
 inppl1b ELISA Kit
 inppl1b Recombinant
 inppl1b Antibody
 inppl1 ELISA Kit
 inppl1 Recombinant
 inppl1 Antibody
 ship2b ELISA Kit
 ship2b Recombinant
 ship2b Antibody
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