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Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

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Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Below are the list of possible Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein ELISA Kit
 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Recombinant
 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody
Also known as Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1).
PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of
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heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; plasma membrane

Molecular Function: enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; negative regulation of protein kinase activity; negative regulation of TOR signaling pathway; neutrophil activation; superoxide metabolic process
 PREX1 ELISA Kit
 PREX1 Recombinant
 PREX1 Antibody
 KIAA1415 ELISA Kit
 KIAA1415 Recombinant
 KIAA1415 Antibody
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