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Phosphatidylinositol 3-kinase regulatory

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Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Below are the list of possible Phosphatidylinositol 3-kinase regulatory products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylinositol 3-kinase regulatory subunit alpha

 Phosphatidylinositol 3-kinase regulatory subunit alpha ELISA Kit
 Phosphatidylinositol 3-kinase regulatory subunit alpha Recombinant
 Phosphatidylinositol 3-kinase regulatory subunit alpha Antibody
Also known as Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha).
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2
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domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement ().
 PIK3R1 ELISA Kit
 PIK3R1 Recombinant
 PIK3R1 Antibody
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Phosphatidylinositol 3-kinase regulatory subunit beta

 Phosphatidylinositol 3-kinase regulatory subunit beta ELISA Kit
 Phosphatidylinositol 3-kinase regulatory subunit beta Recombinant
 Phosphatidylinositol 3-kinase regulatory subunit beta Antibody
Also known as Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta).
PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a
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subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis

Cellular Component: focal adhesion; nucleus; phosphoinositide 3-kinase complex

Molecular Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity; protein binding; protein heterodimerization activity; protein phosphatase binding; receptor tyrosine kinase binding; transcription factor binding

Biological Process: cell glucose homeostasis; cellular response to insulin stimulus; insulin receptor signaling pathway; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of actin filament polymerization; regulation of autophagy; regulation of phosphoinositide 3-kinase activity; regulation of stress fiber formation
 Pik3r2 ELISA Kit
 Pik3r2 Recombinant
 Pik3r2 Antibody
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Phosphatidylinositol 3-kinase regulatory subunit gamma

 Phosphatidylinositol 3-kinase regulatory subunit gamma ELISA Kit
 Phosphatidylinositol 3-kinase regulatory subunit gamma Recombinant
 Phosphatidylinositol 3-kinase regulatory subunit gamma Antibody
Also known as Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK).
PIK3R3: Binds to activated (phosphorylated) protein-tyrosine ki
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nases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis

Cellular Component: phosphoinositide 3-kinase complex

Molecular Function: 1-phosphatidylinositol-3-kinase regulator activity

Biological Process: insulin receptor signaling pathway
 Pik3r3 ELISA Kit
 Pik3r3 Recombinant
 Pik3r3 Antibody
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