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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing

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Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

Below are the list of possible Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha ELISA Kit
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Recombinant
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Antibody
Also known as Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (Cpk-m) (Phosphoinositide 3-kinase-C2-alpha) (p170).
PIK3C2A: a protein of the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration,
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and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. Its PI3-kinase is not sensitive to nanomolar levels of the inhibitor wortmannin. Activated by insulin and may be involved in integrin-dependent signaling.

Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; membrane; phosphoinositide 3-kinase complex; plasma membrane; vesicle

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity

Biological Process: cellular response to starvation; endocytosis; macroautophagy
 Pik3c2a ELISA Kit
 Pik3c2a Recombinant
 Pik3c2a Antibody
 Cpk ELISA Kit
 Cpk Recombinant
 Cpk Antibody
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta ELISA Kit
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Recombinant
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Antibody
Also known as Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta).
PIK3C2B: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. Belongs to the PI3/PI4-kinase family.

Pr
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otein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cytosol; phosphoinositide 3-kinase complex; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; protein binding

Biological Process: phosphatidylinositol biosynthetic process
 PIK3C2B ELISA Kit
 PIK3C2B Recombinant
 PIK3C2B Antibody
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma ELISA Kit
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Recombinant
 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Antibody
Also known as Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (Phosphoinositide 3-kinase-C2-gamma).
PIK3C2G: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity) >>>
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Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis

Cellular Component: Golgi apparatus; nuclear envelope; phosphoinositide 3-kinase complex; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity

Biological Process: chemotaxis
 Pik3c2g ELISA Kit
 Pik3c2g Recombinant
 Pik3c2g Antibody
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