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Photoreceptor-specific nuclear receptor

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Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.

Below are the list of possible Photoreceptor-specific nuclear receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Photoreceptor-specific nuclear receptor

 Photoreceptor-specific nuclear receptor ELISA Kit
 Photoreceptor-specific nuclear receptor Recombinant
 Photoreceptor-specific nuclear receptor Antibody
Also known as Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor).
NR2E3: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS). ESCS
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is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor

Cellular Component: nucleus; transcription factor complex

Molecular Function: protein binding; transcription factor activity

Biological Process: eye photoreceptor cell development; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; retina development in camera-type eye
 Nr2e3 ELISA Kit
 Nr2e3 Recombinant
 Nr2e3 Antibody
 Pnr ELISA Kit
 Pnr Recombinant
 Pnr Antibody
 Rnr ELISA Kit
 Rnr Recombinant
 Rnr Antibody
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