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PKS-NRPS hybrid synthetase

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PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells .

Below are the list of possible PKS-NRPS hybrid synthetase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PKS-NRPS hybrid synthetase CHGG_01239

 PKS-NRPS hybrid synthetase CHGG_01239 ELISA Kit
 PKS-NRPS hybrid synthetase CHGG_01239 Recombinant
 PKS-NRPS hybrid synthetase CHGG_01239 Antibody
Also known as PKS-NRPS hybrid synthetase CHGG_01239 (PKS-NRPS) (Chaetoglobosin biosynthesis protein CHGG_01239) (Prochaetoglobin I synthase).
PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317). The first step of the pathway is the synthesi
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s of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase CHGG_01239, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase CHGG_01240 (PubMed:23611317). Further multiple oxidation steps performed by the cytochrome P450 monooxygenases CHGG_01242-1 and CHGG_01243, as well as by the FAD-linked oxidoreductase CHGG_01242-2, lead to the formation of chaetoglobosin A (PubMed:23611317). Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317). Within the pathway, the cytochrome P450 monooxygenase CHGG_01242-1 catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317). The FAD-linked oxidoreductase CHGG_01242-2 performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317). Finally, the cytochrome P450 monooxygenase CHGG_01243 can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317).
 CHGG_01239 ELISA Kit
 CHGG_01239 Recombinant
 CHGG_01239 Antibody
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PKS-NRPS hybrid synthetase psoA

 PKS-NRPS hybrid synthetase psoA ELISA Kit
 PKS-NRPS hybrid synthetase psoA Recombinant
 PKS-NRPS hybrid synthetase psoA Antibody
Also known as PKS-NRPS hybrid synthetase psoA (Nonribosomal peptide synthetase 14) (NRPS14) (Pseurotin biosynthesis protein A).
PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation (PubMed:17722120, PubMed:17464044, PubMed:24082142, PubMed:24939566). The PKS-NRPS hybrid synthetase psoA is responsible for the biosynthesis of azaspirene, one of the first intermediates having the 1-oxa-7-azaspiro[4,4]-non-2-ene-4,6-dione core of pseurotin, via condensation of one
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acetyl-CoA, 4 malonyl-CoA, and a L-phenylalanine molecule (PubMed:24082142, PubMed:24939566). The dual-functional monooxygenase/methyltransferase psoF seems to be involved in the addition of the C3 methyl group onto the pseurotin scaffold (PubMed:24939566). Azaspirene is then converted to synerazol through 4 steps including oxidation of C17 by the cytochrome P450 monooxygenase psoD, O-methylation of the hydroxy group of C8 by the methyltransferase psoC, and the trans-to-cis isomerization of the C13 olefin by the glutathione S-transferase psoE (PubMed:24939566). The fourth step of synerazol production is performed by the dual-functional monooxygenase/methyltransferase psoF which seems to catalyze the epoxidation of the intermediate deepoxy-synerazol (PubMed:24939566). Synerazol can be attacked by a water molecule nonenzymatically at two different positions to yield two diol products, pseurotin A and pseurotin D (PubMed:24939566).
 NRPS14 ELISA Kit
 NRPS14 Recombinant
 NRPS14 Antibody
 pesO ELISA Kit
 pesO Recombinant
 pesO Antibody
 AFUA_8G00540 ELISA Kit
 AFUA_8G00540 Recombinant
 AFUA_8G00540 Antibody
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