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Plakophilin

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Seems to play a role in junctional plaques.

Below are the list of possible Plakophilin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Plakophilin-1

 Plakophilin-1 ELISA Kit
 Plakophilin-1 Recombinant
 Plakophilin-1 Antibody
plakophilin 1: Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. Defects in PKP1 are the cause of ectodermal dysplasia- skin fragility syndrome (EDSFS); also known as McGrath syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSFS is characterized by features of both cutaneou
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s fragility and congenital ectodermal dysplasia affecting abnormalities in other epithelia or tissues. Desmosomes in the skin are small and poorly formed with widening of keratinocyte intercellular spaces and perturbed desmosome/keratin intermediate filament interactions. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: desmosome; intracellular membrane-bound organelle; nucleoplasm; nucleus; plasma membrane

Molecular Function: lamin binding; protein binding

Biological Process: intermediate filament bundle assembly
 Pkp1 ELISA Kit
 Pkp1 Recombinant
 Pkp1 Antibody
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Plakophilin-2

 Plakophilin-2 ELISA Kit
 Plakophilin-2 Recombinant
 Plakophilin-2 Antibody
plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinic
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ally defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: adherens junction; cell junction; cell-cell adherens junction; desmosome; integral to membrane; intercellular junction; intermediate filament; nucleoplasm; plasma membrane

Molecular Function: alpha-catenin binding; intermediate filament binding; protein binding; protein complex scaffold; protein kinase C binding; sodium channel regulator activity

Biological Process: cell-cell adhesion; gap junction assembly; heart development; intermediate filament bundle assembly; lipid homeostasis; maintenance of organ identity; negative regulation of cell migration; negative regulation of cell proliferation; ventricular cardiac muscle morphogenesis

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
 PKP2 ELISA Kit
 PKP2 Recombinant
 PKP2 Antibody
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Plakophilin-3

 Plakophilin-3 ELISA Kit
 Plakophilin-3 Recombinant
 Plakophilin-3 Antibody
May play a role in junctional plaques.
 PKP3 ELISA Kit
 PKP3 Recombinant
 PKP3 Antibody
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Plakophilin-4

 Plakophilin-4 ELISA Kit
 Plakophilin-4 Recombinant
 Plakophilin-4 Antibody
Also known as Plakophilin-4 (Armadillo-related protein).
plakophilin 4: an armadillo-like protein of the beta-catenin family. A component of desmosomal plaques and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Two splice-variant isoforms have been described

Protein type: Cell adhesion

Cellular Component: ce
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ll junction; cytoplasm; cytoskeleton; desmosome; intercellular junction; internal side of plasma membrane; midbody; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; spindle midzone; spindle pole

Biological Process: intercellular junction assembly; positive regulation of cytokinesis; positive regulation of GTPase activity
 Pkp4 ELISA Kit
 Pkp4 Recombinant
 Pkp4 Antibody
 Armrp ELISA Kit
 Armrp Recombinant
 Armrp Antibody
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