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Platelet-activating factor acetylhydrolase

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Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Below are the list of possible Platelet-activating factor acetylhydrolase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Platelet-activating factor acetylhydrolase

 Platelet-activating factor acetylhydrolase ELISA Kit
 Platelet-activating factor acetylhydrolase Recombinant
 Platelet-activating factor acetylhydrolase Antibody
Also known as Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (.
PLA2G7: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-
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PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD). An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. Asthmatic individuals affected by this condition may manifest severe respiratory symptoms. Defects in PLA2G7 are a cause of susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. PLA2G7 variants can be a risk factor for the development of asthma and PLA2G7 may act as a modifier gene that modulates the severity of this disease. Defects in PLA2G7 are a cause of susceptibility to atopic hypersensitivity (ATOPY). A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: EC 3.1.1.47; Hydrolase; Lipid Metabolism - ether lipid; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p21.2-p12

Cellular Component: extracellular region

Molecular Function: 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; hydrolase activity, acting on ester bonds; phospholipid binding

Biological Process: platelet activating factor metabolic process; positive regulation of inflammatory response

Disease: Asthma, Susceptibility To; Ige Responsiveness, Atopic; Platelet-activating Factor Acetylhydrolase Deficiency
 PLA2G7 ELISA Kit
 PLA2G7 Recombinant
 PLA2G7 Antibody
 PAFAH ELISA Kit
 PAFAH Recombinant
 PAFAH Antibody
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Platelet-activating factor acetylhydrolase 2, cytoplasmic

 Platelet-activating factor acetylhydrolase 2, cytoplasmic ELISA Kit
 Platelet-activating factor acetylhydrolase 2, cytoplasmic Recombinant
 Platelet-activating factor acetylhydrolase 2, cytoplasmic Antibody
Also known as Platelet-activating factor acetylhydrolase 2, cytoplasmic (Serine-dependent phospholipase A2) (SD-PLA2).
PAFAH2: Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. Belongs to the serine esterase family.

Protein type: EC 3.1.1.47; Hydrolase; Lipid Metabolism - ether lipi
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d; Lipid-binding

Molecular Function: 1-alkyl-2-acetylglycerophosphocholine esterase activity

Biological Process: negative regulation of apoptosis
 Pafah2 ELISA Kit
 Pafah2 Recombinant
 Pafah2 Antibody
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Platelet-activating factor acetylhydrolase homolog 2

 Platelet-activating factor acetylhydrolase homolog 2 ELISA Kit
 Platelet-activating factor acetylhydrolase homolog 2 Recombinant
 Platelet-activating factor acetylhydrolase homolog 2 Antibody
 paf-2 ELISA Kit
 paf-2 Recombinant
 paf-2 Antibody
 C52B9.7 ELISA Kit
 C52B9.7 Recombinant
 C52B9.7 Antibody
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Platelet-activating factor acetylhydrolase IB subunit alpha

 Platelet-activating factor acetylhydrolase IB subunit alpha ELISA Kit
 Platelet-activating factor acetylhydrolase IB subunit alpha Recombinant
 Platelet-activating factor acetylhydrolase IB subunit alpha Antibody
Also known as Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha).
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.
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Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
 PAFAH1B1 ELISA Kit
 PAFAH1B1 Recombinant
 PAFAH1B1 Antibody
 LIS1 ELISA Kit
 LIS1 Recombinant
 LIS1 Antibody
 PAFAHA ELISA Kit
 PAFAHA Recombinant
 PAFAHA Antibody
 QflA-10848 ELISA Kit
 QflA-10848 Recombinant
 QflA-10848 Antibody
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Platelet-activating factor acetylhydrolase IB subunit beta

 Platelet-activating factor acetylhydrolase IB subunit beta ELISA Kit
 Platelet-activating factor acetylhydrolase IB subunit beta Recombinant
 Platelet-activating factor acetylhydrolase IB subunit beta Antibody
Also known as Platelet-activating factor acetylhydrolase IB subunit beta (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta).
Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit ().
 PAFAH1B2 ELISA Kit
 PAFAH1B2 Recombinant
 PAFAH1B2 Antibody
 PAFAHB ELISA Kit
 PAFAHB Recombinant
 PAFAHB Antibody
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Platelet-activating factor acetylhydrolase IB subunit beta homolog

 Platelet-activating factor acetylhydrolase IB subunit beta homolog ELISA Kit
 Platelet-activating factor acetylhydrolase IB subunit beta homolog Recombinant
 Platelet-activating factor acetylhydrolase IB subunit beta homolog Antibody
Enzyme and pathway databasesReactome - a knowledgebase of biological pathways and processes<br/><a href='/database/88'>More..</a>ReactomeiR-DME-6798695. Neutrophil degranulation. R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.
 Paf-AHalpha ELISA Kit
 Paf-AHalpha Recombinant
 Paf-AHalpha Antibody
 CG8962 ELISA Kit
 CG8962 Recombinant
 CG8962 Antibody
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Platelet-activating factor acetylhydrolase IB subunit gamma

 Platelet-activating factor acetylhydrolase IB subunit gamma ELISA Kit
 Platelet-activating factor acetylhydrolase IB subunit gamma Recombinant
 Platelet-activating factor acetylhydrolase IB subunit gamma Antibody
Also known as Platelet-activating factor acetylhydrolase IB subunit gamma (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma).
PAFAH1B3: Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. Belongs to the 'GDSL' lipolytic enzyme family. Platel
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et-activating factor acetylhydrolase IB beta/gamma subunits subfamily.

Protein type: EC 3.1.1.47; Lipase; Lipid Metabolism - ether lipid

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function: identical protein binding; platelet-activating factor acetyltransferase activity; protein heterodimerization activity

Biological Process: brain development; spermatogenesis
 Pafah1b3 ELISA Kit
 Pafah1b3 Recombinant
 Pafah1b3 Antibody
 Pafahg ELISA Kit
 Pafahg Recombinant
 Pafahg Antibody
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