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Platelet endothelial cell adhesion molecule

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis (By similarity).

Below are the list of possible Platelet endothelial cell adhesion molecule products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Platelet endothelial cell adhesion molecule

 Platelet endothelial cell adhesion molecule ELISA Kit
 Platelet endothelial cell adhesion molecule Recombinant
 Platelet endothelial cell adhesion molecule Antibody
Also known as Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31).
PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage p
hagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: cell surface; external side of plasma membrane; extracellular space; lipid raft; membrane; plasma membrane; ruffle; smooth muscle contractile fiber

Molecular Function: protein phosphatase binding

Biological Process: angiogenesis; diapedesis; endothelial cell migration; endothelial cell morphogenesis; negative regulation of actin filament polymerization; negative regulation of peptidyl-tyrosine phosphorylation; phagocytosis; positive regulation of cellular extravasation; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of cell migration; Rho protein signal transduction; wound healing
 Pecam1 ELISA Kit
 Pecam1 Recombinant
 Pecam1 Antibody
 Pecam ELISA Kit
 Pecam Recombinant
 Pecam Antibody
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