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Plexin

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Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Below are the list of possible Plexin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Plexin A3

 Plexin A3 ELISA Kit
 Plexin A3 Recombinant
 Plexin A3 Antibody
Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activat
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ion of down-stream signaling events in the cytoplasm.
 plxna3 ELISA Kit
 plxna3 Recombinant
 plxna3 Antibody
 si:dkey-7i23.3 ELISA Kit
 si:dkey-7i23.3 Recombinant
 si:dkey-7i23.3 Antibody
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Plexin-2

 Plexin-2 ELISA Kit
 Plexin-2 Recombinant
 Plexin-2 Antibody
Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays ().
 plx-2 ELISA Kit
 plx-2 Recombinant
 plx-2 Antibody
 CBG00979 ELISA Kit
 CBG00979 Recombinant
 CBG00979 Antibody
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Plexin-A1

 Plexin-A1 ELISA Kit
 Plexin-A1 Recombinant
 Plexin-A1 Antibody
Also known as Plexin-A1 (Plex 1) (Plexin-1).
PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for spe
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cific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: cytoplasm; integral to plasma membrane; membrane; nucleus

Molecular Function: protein binding; semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; regulation of axon extension involved in axon guidance; regulation of smooth muscle cell migration
 Plxna1 ELISA Kit
 Plxna1 Recombinant
 Plxna1 Antibody
 Kiaa4053 ELISA Kit
 Kiaa4053 Recombinant
 Kiaa4053 Antibody
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Plexin-A2

 Plexin-A2 ELISA Kit
 Plexin-A2 Recombinant
 Plexin-A2 Antibody
Also known as Plexin-A2 (Plex 2) (Plexin-2).
PLXNA2: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific
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semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2. Interacts with RND1. Detected in fetal brain. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: integral to plasma membrane

Molecular Function: semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; cell surface receptor linked signal transduction; centrosome localization; granule cell precursor tangential migration; limb bud formation; neural tube development; pharyngeal system development; regulation of axon extension involved in axon guidance; regulation of cell migration; somitogenesis
 Plxna2 ELISA Kit
 Plxna2 Recombinant
 Plxna2 Antibody
 Kiaa0463 ELISA Kit
 Kiaa0463 Recombinant
 Kiaa0463 Antibody
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Plexin-A3

 Plexin-A3 ELISA Kit
 Plexin-A3 Recombinant
 Plexin-A3 Antibody
PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediate
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d programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family.

Protein type: Membrane protein, integral

Cellular Component: cell junction; integral to plasma membrane; intracellular membrane-bound organelle; nucleus; plasma membrane

Molecular Function: semaphorin receptor activity

Biological Process: axon guidance; branchiomotor neuron axon guidance; facial nerve structural organization; hippocampus development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; regulation of cell migration; trigeminal nerve structural organization
 Plxna3 ELISA Kit
 Plxna3 Recombinant
 Plxna3 Antibody
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Plexin-A4

 Plexin-A4 ELISA Kit
 Plexin-A4 Recombinant
 Plexin-A4 Antibody
PLXNA4: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type:
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Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q32.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; regulation of axon extension involved in axon guidance; regulation of cell migration
 PLXNA4 ELISA Kit
 PLXNA4 Recombinant
 PLXNA4 Antibody
 KIAA1550 ELISA Kit
 KIAA1550 Recombinant
 KIAA1550 Antibody
 PLXNA4A ELISA Kit
 PLXNA4A Recombinant
 PLXNA4A Antibody
 PLXNA4B ELISA Kit
 PLXNA4B Recombinant
 PLXNA4B Antibody
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Plexin-B

 Plexin-B ELISA Kit
 Plexin-B Recombinant
 Plexin-B Antibody
Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity.
 PlexB ELISA Kit
 PlexB Recombinant
 PlexB Antibody
 CG17245 ELISA Kit
 CG17245 Recombinant
 CG17245 Antibody
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Plexin-B1

 Plexin-B1 ELISA Kit
 Plexin-B1 Recombinant
 Plexin-B1 Antibody
PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component:
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integral to plasma membrane

Molecular Function: GTPase activating protein binding; protein binding; semaphorin receptor activity

Biological Process: axon extension; negative regulation of cell adhesion; negative regulation of osteoblast proliferation; neurite morphogenesis; positive regulation of axonogenesis; positive regulation of GTPase activity; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell migration; regulation of cell shape; regulation of cytoskeleton organization and biogenesis
 Plxnb1 ELISA Kit
 Plxnb1 Recombinant
 Plxnb1 Antibody
 Kiaa0407 ELISA Kit
 Kiaa0407 Recombinant
 Kiaa0407 Antibody
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Plexin-B2

 Plexin-B2 ELISA Kit
 Plexin-B2 Recombinant
 Plexin-B2 Antibody
PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebe
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llar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family.

Protein type: Membrane protein, integral

Cellular Component: cell surface; integral to plasma membrane

Molecular Function: protein binding; semaphorin receptor activity

Biological Process: brain development; homophilic cell adhesion; negative regulation of cell adhesion; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of cell shape; regulation of GTPase activity; regulation of protein amino acid phosphorylation
 Plxnb2 ELISA Kit
 Plxnb2 Recombinant
 Plxnb2 Antibody
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Plexin-B3

 Plexin-B3 ELISA Kit
 Plexin-B3 Recombinant
 Plexin-B3 Antibody
PLXNB3: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Belongs to the plexin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cell sur
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face; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protein domain specific binding; semaphorin receptor activity

Biological Process: homophilic cell adhesion; negative regulation of cell adhesion; negative regulation of cell migration; positive chemotaxis; positive regulation of axonogenesis; positive regulation of endothelial cell proliferation; regulation of cell shape
 PLXNB3 ELISA Kit
 PLXNB3 Recombinant
 PLXNB3 Antibody
 KIAA1206 ELISA Kit
 KIAA1206 Recombinant
 KIAA1206 Antibody
 PLXN6 ELISA Kit
 PLXN6 Recombinant
 PLXN6 Antibody
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Plexin-C1

 Plexin-C1 ELISA Kit
 Plexin-C1 Recombinant
 Plexin-C1 Antibody
Also known as Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232).
PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.

Protein type: C
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ell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q23.3

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: protein binding; receptor binding; semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; cell adhesion; regulation of axon extension involved in axon guidance; regulation of cell migration
 PLXNC1 ELISA Kit
 PLXNC1 Recombinant
 PLXNC1 Antibody
 VESPR ELISA Kit
 VESPR Recombinant
 VESPR Antibody
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Plexin-D1

 Plexin-D1 ELISA Kit
 Plexin-D1 Recombinant
 Plexin-D1 Antibody
PLXND1: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for no
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rmal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: integral to plasma membrane; lamellipodium; plasma membrane

Molecular Function: protein binding; protein domain specific binding; semaphorin receptor activity

Biological Process: angiogenesis; branchiomotor neuron axon guidance; endothelial cell migration; regulation of angiogenesis; regulation of axon extension involved in axon guidance; regulation of cell migration; synaptogenesis
 PLXND1 ELISA Kit
 PLXND1 Recombinant
 PLXND1 Antibody
 KIAA0620 ELISA Kit
 KIAA0620 Recombinant
 KIAA0620 Antibody
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