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PMS1 protein

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Probably involved in the repair of mismatches in DNA.

Below are the list of possible PMS1 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PMS1 protein homolog 1

 PMS1 protein homolog 1 ELISA Kit
 PMS1 protein homolog 1 Recombinant
 PMS1 protein homolog 1 Antibody
Also known as PMS1 protein homolog 1 (DNA mismatch repair protein PMS1).
PMS1: Probably involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with cli
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nically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Belongs to the DNA mismatch repair MutL/HexB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Tumor suppressor

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: chiasma; MutLalpha complex; nucleus; synaptonemal complex

Molecular Function: ATPase activity; DNA binding; single-stranded DNA binding

Disease: Lynch Syndrome I
 PMS1 ELISA Kit
 PMS1 Recombinant
 PMS1 Antibody
 PMSL1 ELISA Kit
 PMSL1 Recombinant
 PMSL1 Antibody
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