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Poly(A)-specific ribonuclease

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3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Below are the list of possible Poly(A)-specific ribonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Poly(A)-specific ribonuclease PARN

 Poly(A)-specific ribonuclease PARN ELISA Kit
 Poly(A)-specific ribonuclease PARN Recombinant
 Poly(A)-specific ribonuclease PARN Antibody
Also known as Poly(A)-specific ribonuclease PARN (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease).
PARN: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain
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maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Homodimer. Interacts with KHSRP and CELF1/CUGBP1. Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Ubiquitous. Belongs to the CAF1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: cation binding; mRNA 3'-UTR binding; nuclease activity; poly(A)-specific ribonuclease activity; protein binding; protein kinase binding

Biological Process: female gamete generation; mRNA catabolic process, nonsense-mediated decay; poly(A) tail shortening; regulation of mRNA stability; RNA modification

Disease: Dyskeratosis Congenita, Autosomal Recessive, 6; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 4
 PARN ELISA Kit
 PARN Recombinant
 PARN Antibody
 DAN ELISA Kit
 DAN Recombinant
 DAN Antibody
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Poly(A)-specific ribonuclease PARN-like

 Poly(A)-specific ribonuclease PARN-like ELISA Kit
 Poly(A)-specific ribonuclease PARN-like Recombinant
 Poly(A)-specific ribonuclease PARN-like Antibody
Also known as Poly(A)-specific ribonuclease PARN-like (Polyadenylate-specific ribonuclease-like protein).
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs ().
 At3g25430 ELISA Kit
 At3g25430 Recombinant
 At3g25430 Antibody
 MWL2.4 ELISA Kit
 MWL2.4 Recombinant
 MWL2.4 Antibody
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