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Polycomb protein

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Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development.

Below are the list of possible Polycomb protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Polycomb protein Asx

 Polycomb protein Asx ELISA Kit
 Polycomb protein Asx Recombinant
 Polycomb protein Asx Antibody
Also known as Polycomb protein Asx (Additional sex combs).
Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B.
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Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development.
 Asx ELISA Kit
 Asx Recombinant
 Asx Antibody
 CG8787 ELISA Kit
 CG8787 Recombinant
 CG8787 Antibody
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Polycomb protein EED

 Polycomb protein EED ELISA Kit
 Polycomb protein EED Recombinant
 Polycomb protein EED Antibody
EED: a member of the superfamily of Polycomb group (PcG) methyltransferase proteins with WD-40 repeats. PcG complexes mediate chromatin modifications that contribute to transcriptional silencing during development and carcinogenesis. A part of the Polycomb-repressive complex 2 (PRC2) along with EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. Interacts with HDAC, HDAC2, histone H1 and YY1. PRC2 t
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rimethylates histone H3 on K9 and K27, transcriptionally repressing target gene including HOXC8, HOXA9, MYT1 and CDKN2A. Appears to be overexpressed in breast and colon cancers. Inhibitors of PRC2-mediated gene repression are being investigated as a cancer therapy. EED and EZH2 are also implicated in the silencing of the inactive X chromosome. Three human isoforms produced by alternative splicing or initiation have been described, and additional isoforms may be produced by alternative initiation.

Protein type: Methyltransferase

Cellular Component: ESC/E(Z) complex; nucleolus; nucleus; pronucleus; sex chromatin

Molecular Function: chromatin binding; histone methyltransferase activity; protein binding

Biological Process: genetic imprinting; histone methylation; negative regulation of transcription from RNA polymerase II promoter
 Eed ELISA Kit
 Eed Recombinant
 Eed Antibody
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Polycomb protein eed-A

 Polycomb protein eed-A ELISA Kit
 Polycomb protein eed-A Recombinant
 Polycomb protein eed-A Antibody
Also known as Polycomb protein eed-A (Xeed-A).
Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene ().
 eed-a ELISA Kit
 eed-a Recombinant
 eed-a Antibody
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Polycomb protein eed-B

 Polycomb protein eed-B ELISA Kit
 Polycomb protein eed-B Recombinant
 Polycomb protein eed-B Antibody
Also known as Polycomb protein eed-B (Xeed-B) (psXEED).
Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (). May play a role in neural induction.
 eed-b ELISA Kit
 eed-b Recombinant
 eed-b Antibody
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Polycomb protein esc

 Polycomb protein esc ELISA Kit
 Polycomb protein esc Recombinant
 Polycomb protein esc Antibody
Also known as Polycomb protein esc (Protein extra sex combs).
Polycomb group (PcG) protein. In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG prote
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ins are not required to initiate repression, but to maintain it during later stages of development. They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression ().
 esc ELISA Kit
 esc Recombinant
 esc Antibody
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Polycomb protein mes-3

 Polycomb protein mes-3 ELISA Kit
 Polycomb protein mes-3 Recombinant
 Polycomb protein mes-3 Antibody
Also known as Polycomb protein mes-3 (Maternal-effect sterile protein 3).
Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The m
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es-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells.
 mes-3 ELISA Kit
 mes-3 Recombinant
 mes-3 Antibody
 F54C1.3 ELISA Kit
 F54C1.3 Recombinant
 F54C1.3 Antibody
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Polycomb protein mes-6

 Polycomb protein mes-6 ELISA Kit
 Polycomb protein mes-6 Recombinant
 Polycomb protein mes-6 Antibody
Also known as Polycomb protein mes-6 (ESC homolog) (Maternal-effect sterile protein 6).
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The me
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s-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
 mes-6 ELISA Kit
 mes-6 Recombinant
 mes-6 Antibody
 C09G4.5 ELISA Kit
 C09G4.5 Recombinant
 C09G4.5 Antibody
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Polycomb protein Pcl

 Polycomb protein Pcl ELISA Kit
 Polycomb protein Pcl Recombinant
 Polycomb protein Pcl Antibody
Also known as Polycomb protein Pcl (Polycomblike protein).
Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9'
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and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. Required for the correct spatial expression of the homeotic genes of the Antennapedia and Bithorax complexes.
 Pcl ELISA Kit
 Pcl Recombinant
 Pcl Antibody
 CG5109 ELISA Kit
 CG5109 Recombinant
 CG5109 Antibody
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Polycomb protein PHO

 Polycomb protein PHO ELISA Kit
 Polycomb protein PHO Recombinant
 Polycomb protein PHO Antibody
Also known as Polycomb protein PHO (Protein pleiohomeotic) (Transcription factor YY1 homolog).
Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are
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not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
 pho ELISA Kit
 pho Recombinant
 pho Antibody
 CG17743 ELISA Kit
 CG17743 Recombinant
 CG17743 Antibody
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Polycomb protein Scm

 Polycomb protein Scm ELISA Kit
 Polycomb protein Scm Recombinant
 Polycomb protein Scm Antibody
Also known as Polycomb protein Scm (Sex comb on midleg protein).
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the met
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hylation of histones, rendering chromatin heritably changed in its expressibility.
 Scm ELISA Kit
 Scm Recombinant
 Scm Antibody
 CG9495 ELISA Kit
 CG9495 Recombinant
 CG9495 Antibody
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Polycomb protein SCMH1

 Polycomb protein SCMH1 ELISA Kit
 Polycomb protein SCMH1 Recombinant
 Polycomb protein SCMH1 Antibody
Also known as Polycomb protein SCMH1 (Sex comb on midleg homolog 1).
SCMH1: Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. Belongs to the SCM family. 6 isoforms of the human protein are produced by alternative splicing.

Cellular Component: chromocenter; nucleus

Molecular F
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unction: protein binding

Biological Process: anterior/posterior pattern formation; chromatin remodeling; negative regulation of transcription, DNA-dependent; spermatogenesis
 Scmh1 ELISA Kit
 Scmh1 Recombinant
 Scmh1 Antibody
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Polycomb protein Sfmbt

 Polycomb protein Sfmbt ELISA Kit
 Polycomb protein Sfmbt Recombinant
 Polycomb protein Sfmbt Antibody
Also known as Polycomb protein Sfmbt (Scm-like with four MBT domain-containing protein 1).
Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins a
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re not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression ().
 Sfmbt ELISA Kit
 Sfmbt Recombinant
 Sfmbt Antibody
 GA14249 ELISA Kit
 GA14249 Recombinant
 GA14249 Antibody
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Polycomb protein sop-2

 Polycomb protein sop-2 ELISA Kit
 Polycomb protein sop-2 Recombinant
 Polycomb protein sop-2 Antibody
Also known as Polycomb protein sop-2 (Suppressor of pal-1 protein 2).
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress
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expression of other genes and for localization of sor-1. Binds RNA.
 sop-2 ELISA Kit
 sop-2 Recombinant
 sop-2 Antibody
 C50E10.4 ELISA Kit
 C50E10.4 Recombinant
 C50E10.4 Antibody
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Polycomb protein Su

 Polycomb protein Su ELISA Kit
 Polycomb protein Su Recombinant
 Polycomb protein Su Antibody
Also known as Polycomb protein Su(z)12 (Suppressor 12 of zeste protein).
Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which meth
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ylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
 Su(z)12 ELISA Kit
 Su(z)12 Recombinant
 Su(z)12 Antibody
 CG8013 ELISA Kit
 CG8013 Recombinant
 CG8013 Antibody
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Polycomb protein SUZ12

 Polycomb protein SUZ12 ELISA Kit
 Polycomb protein SUZ12 Recombinant
 Polycomb protein SUZ12 Antibody
Also known as Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog).
SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; histone methyltransfera
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se activity; methylated histone residue binding; protein binding

Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent
 SUZ12 ELISA Kit
 SUZ12 Recombinant
 SUZ12 Antibody
 CHET9 ELISA Kit
 CHET9 Recombinant
 CHET9 Antibody
 JJAZ1 ELISA Kit
 JJAZ1 Recombinant
 JJAZ1 Antibody
 KIAA0160 ELISA Kit
 KIAA0160 Recombinant
 KIAA0160 Antibody
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Polycomb protein suz12-A

 Polycomb protein suz12-A ELISA Kit
 Polycomb protein suz12-A Recombinant
 Polycomb protein suz12-A Antibody
Also known as Polycomb protein suz12-A (Suppressor of zeste 12 protein homolog A).
Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene ().
 suz12a ELISA Kit
 suz12a Recombinant
 suz12a Antibody
 suz12 ELISA Kit
 suz12 Recombinant
 suz12 Antibody
 suz12l ELISA Kit
 suz12l Recombinant
 suz12l Antibody
 zgc:100863 ELISA Kit
 zgc:100863 Recombinant
 zgc:100863 Antibody
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Polycomb protein suz12-B

 Polycomb protein suz12-B ELISA Kit
 Polycomb protein suz12-B Recombinant
 Polycomb protein suz12-B Antibody
Also known as Polycomb protein suz12-B (Suppressor of zeste 12 protein homolog B).
Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene ().
 suz12b ELISA Kit
 suz12b Recombinant
 suz12b Antibody
 suz12 ELISA Kit
 suz12 Recombinant
 suz12 Antibody
 si:dkey-10p5.2 ELISA Kit
 si:dkey-10p5.2 Recombinant
 si:dkey-10p5.2 Antibody
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