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Polycystin

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Involved in renal tubulogenesis . The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.

Below are the list of possible Polycystin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Polycystin-1

 Polycystin-1 ELISA Kit
 Polycystin-1 Recombinant
 Polycystin-1 Antibody
Also known as Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog).
PKD1: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length resp
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onse creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion- channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Defects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1). ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000. Belongs to the polycystin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: basolateral plasma membrane; cell surface; cilium; cytoplasm; Golgi apparatus; lateral plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: calcium channel activity; cation channel activity; protein binding; protein domain specific binding; protein kinase binding

Biological Process: blood vessel development; branching morphogenesis of a tube; calcium ion transport; cartilage condensation; cell cycle arrest; cell-cell adhesion; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; elevation of cytosolic calcium ion concentration; embryonic placenta development; establishment of cell polarity; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; heart development; in utero embryonic development; JAK-STAT cascade; kidney development; liver development; nitrogen compound metabolic process; peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of cell adhesion
 Pkd1 ELISA Kit
 Pkd1 Recombinant
 Pkd1 Antibody
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Polycystin-2

 Polycystin-2 ELISA Kit
 Polycystin-2 Recombinant
 Polycystin-2 Antibody
Also known as Polycystin-2 (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2).
PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for norma
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l tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: basal cortex; basal plasma membrane; cilium; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; filamentous actin; integral to plasma membrane; intercellular junction; lamellipodium; plasma membrane

Molecular Function: actinin binding; ATPase binding; calcium ion binding; calcium-induced calcium release activity; cytoskeletal protein binding; HLH domain binding; identical protein binding; phosphoprotein binding; potassium channel activity; protein binding; protein homodimerization activity; receptor binding; voltage-gated calcium channel activity; voltage-gated cation channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity

Biological Process: calcium ion transport; cell cycle arrest; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; determination of left/right symmetry; embryonic placenta development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; heart development; heart looping; JAK-STAT cascade; liver development; neural tube development; positive regulation of inositol-1,4,5-triphosphate receptor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cAMP metabolic process; regulation of cell proliferation; release of sequestered calcium ion into cytosol; spinal cord development; ureteric bud branching

Disease: Polycystic Kidney Disease 2
 PKD2 ELISA Kit
 PKD2 Recombinant
 PKD2 Antibody
 TRPP2 ELISA Kit
 TRPP2 Recombinant
 TRPP2 Antibody
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