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Potassium channel subfamily

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Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity).

Below are the list of possible Potassium channel subfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Potassium channel subfamily K member 1

 Potassium channel subfamily K member 1 ELISA Kit
 Potassium channel subfamily K member 1 Recombinant
 Potassium channel subfamily K member 1 Antibody
Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, bu
>>>
t becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (). Channel activity is modulated by activation of serotonin receptors (). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (). Required for normal ion and water transport in the kidney (). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes ().
 KCNK1 ELISA Kit
 KCNK1 Recombinant
 KCNK1 Antibody
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Potassium channel subfamily K member 10

 Potassium channel subfamily K member 10 ELISA Kit
 Potassium channel subfamily K member 10 Recombinant
 Potassium channel subfamily K member 10 Antibody
Also known as Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).
TREK-2: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. Belongs to the two pore domain potassium
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channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity

Biological Process: stabilization of membrane potential; transport
 KCNK10 ELISA Kit
 KCNK10 Recombinant
 KCNK10 Antibody
 TREK2 ELISA Kit
 TREK2 Recombinant
 TREK2 Antibody
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Potassium channel subfamily K member 12

 Potassium channel subfamily K member 12 ELISA Kit
 Potassium channel subfamily K member 12 Recombinant
 Potassium channel subfamily K member 12 Antibody
Also known as Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2).
tandem pore domain halothane inhibited K(+) channel [RGD, Feb 2006]
 Kcnk12 ELISA Kit
 Kcnk12 Recombinant
 Kcnk12 Antibody
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Potassium channel subfamily K member 13

 Potassium channel subfamily K member 13 ELISA Kit
 Potassium channel subfamily K member 13 Recombinant
 Potassium channel subfamily K member 13 Antibody
Also known as Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1).
KCNK13: Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: inte
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gral to plasma membrane

Molecular Function: potassium ion leak channel activity

Biological Process: stabilization of membrane potential
 Kcnk13 ELISA Kit
 Kcnk13 Recombinant
 Kcnk13 Antibody
 Gm1570 ELISA Kit
 Gm1570 Recombinant
 Gm1570 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 15

 Potassium channel subfamily K member 15 ELISA Kit
 Potassium channel subfamily K member 15 Recombinant
 Potassium channel subfamily K member 15 Antibody
Also known as Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (rTASK-5) (TWIK-related acid-sensitive K(+) channel 5).
KCNK15: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Belongs to the two pore domain potassium channel (TC 1.A.1.8) fami
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ly.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane

Molecular Function: potassium ion leak channel activity; voltage-gated ion channel activity

Biological Process: stabilization of membrane potential
 Kcnk15 ELISA Kit
 Kcnk15 Recombinant
 Kcnk15 Antibody
 Task5 ELISA Kit
 Task5 Recombinant
 Task5 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 16

 Potassium channel subfamily K member 16 ELISA Kit
 Potassium channel subfamily K member 16 Recombinant
 Potassium channel subfamily K member 16 Antibody
Also known as Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1).
KCNK16: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 4 isoforms of the human protein are produced b
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y alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.2-p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity; protein binding

Biological Process: potassium ion transport; stabilization of membrane potential
 KCNK16 ELISA Kit
 KCNK16 Recombinant
 KCNK16 Antibody
 TALK1 ELISA Kit
 TALK1 Recombinant
 TALK1 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 17

 Potassium channel subfamily K member 17 ELISA Kit
 Potassium channel subfamily K member 17 Recombinant
 Potassium channel subfamily K member 17 Antibody
Also known as Potassium channel subfamily K member 17 (2P domain potassium channel Talk-2) (Acid-sensitive potassium channel protein TASK-4) (TWIK-related acid-sensitive K(+) channel 4) (TWIK-related alkaline pH-activated K(+) channel 2) (TALK-2).
KCNK17: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Com
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ponent: integral to plasma membrane; plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity

Biological Process: potassium ion transport; stabilization of membrane potential
 KCNK17 ELISA Kit
 KCNK17 Recombinant
 KCNK17 Antibody
 TALK2 ELISA Kit
 TALK2 Recombinant
 TALK2 Antibody
 TASK4 ELISA Kit
 TASK4 Recombinant
 TASK4 Antibody
 UNQ5816/PRO19634 ELISA Kit
 UNQ5816/PRO19634 Recombinant
 UNQ5816/PRO19634 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 18

 Potassium channel subfamily K member 18 ELISA Kit
 Potassium channel subfamily K member 18 Recombinant
 Potassium channel subfamily K member 18 Antibody
Also known as Potassium channel subfamily K member 18 (Tresk-2) (Two-pore-domain potassium channel TRESK).
mouse homolog induces a time-independent, noninactivating K+ current [RGD, Feb 2006]
 Kcnk18 ELISA Kit
 Kcnk18 Recombinant
 Kcnk18 Antibody
 Tresk-2 ELISA Kit
 Tresk-2 Recombinant
 Tresk-2 Antibody
 Tresk2 ELISA Kit
 Tresk2 Recombinant
 Tresk2 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 2

 Potassium channel subfamily K member 2 ELISA Kit
 Potassium channel subfamily K member 2 Recombinant
 Potassium channel subfamily K member 2 Antibody
Also known as Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Stretch-activated potassium channel TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1).
a large conductance K+ channel [RGD, Feb 2006]
 Kcnk2 ELISA Kit
 Kcnk2 Recombinant
 Kcnk2 Antibody
 Trek ELISA Kit
 Trek Recombinant
 Trek Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 3

 Potassium channel subfamily K member 3 ELISA Kit
 Potassium channel subfamily K member 3 Recombinant
 Potassium channel subfamily K member 3 Antibody
Also known as Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (Cardiac two pore background K(+) channel) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) (cTBAK-1).
KCNK3: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread e
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xpression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ion channel activity; open rectifier potassium channel activity; potassium ion leak channel activity; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: reduction of cytosolic calcium ion concentration; response to drug; stabilization of membrane potential
 Kcnk3 ELISA Kit
 Kcnk3 Recombinant
 Kcnk3 Antibody
 Ctbak ELISA Kit
 Ctbak Recombinant
 Ctbak Antibody
 Task ELISA Kit
 Task Recombinant
 Task Antibody
 Task1 ELISA Kit
 Task1 Recombinant
 Task1 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 4

 Potassium channel subfamily K member 4 ELISA Kit
 Potassium channel subfamily K member 4 Recombinant
 Potassium channel subfamily K member 4 Antibody
Also known as Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK).
an alkali-sensing two-pore K+ channel [RGD, Feb 2006]
 Kcnk4 ELISA Kit
 Kcnk4 Recombinant
 Kcnk4 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 5

 Potassium channel subfamily K member 5 ELISA Kit
 Potassium channel subfamily K member 5 Recombinant
 Potassium channel subfamily K member 5 Antibody
Also known as Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).
KCNK5: pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. Homodimer; disulfide-linked.

Protein type: Channel, potassium; Membrane protein, integral;
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Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: integral to plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity

Biological Process: excretion; potassium ion transport; stabilization of membrane potential
 KCNK5 ELISA Kit
 KCNK5 Recombinant
 KCNK5 Antibody
 TASK2 ELISA Kit
 TASK2 Recombinant
 TASK2 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 6

 Potassium channel subfamily K member 6 ELISA Kit
 Potassium channel subfamily K member 6 Recombinant
 Potassium channel subfamily K member 6 Antibody
Also known as Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).
KCNK6: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: plasma membrane; vo
>>>
ltage-gated potassium channel complex

Molecular Function: inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity

Biological Process: potassium ion transport; stabilization of membrane potential
 KCNK6 ELISA Kit
 KCNK6 Recombinant
 KCNK6 Antibody
 TOSS ELISA Kit
 TOSS Recombinant
 TOSS Antibody
 TWIK2 ELISA Kit
 TWIK2 Recombinant
 TWIK2 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 7

 Potassium channel subfamily K member 7 ELISA Kit
 Potassium channel subfamily K member 7 Recombinant
 Potassium channel subfamily K member 7 Antibody
KCNK7: Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein,
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integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity

Biological Process: potassium ion transport; stabilization of membrane potential
 KCNK7 ELISA Kit
 KCNK7 Recombinant
 KCNK7 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily K member 9

 Potassium channel subfamily K member 9 ELISA Kit
 Potassium channel subfamily K member 9 Recombinant
 Potassium channel subfamily K member 9 Antibody
pH-dependent, voltage-insensitive, background potassium channel protein.
 kcnk9 ELISA Kit
 kcnk9 Recombinant
 kcnk9 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily T member 1

 Potassium channel subfamily T member 1 ELISA Kit
 Potassium channel subfamily T member 1 Recombinant
 Potassium channel subfamily T member 1 Antibody
KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) s
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ubfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane; voltage-gated potassium channel complex

Molecular Function: calcium-activated potassium channel activity; potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport
 Kcnt1 ELISA Kit
 Kcnt1 Recombinant
 Kcnt1 Antibody
 Kiaa1422 ELISA Kit
 Kiaa1422 Recombinant
 Kiaa1422 Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily T member 2

 Potassium channel subfamily T member 2 ELISA Kit
 Potassium channel subfamily T member 2 Recombinant
 Potassium channel subfamily T member 2 Antibody
Also known as Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1).
a K+ channel activated by intracellular Na+ and Cl- and inhibited by intracellular ATP [RGD, Feb 2006]
 Kcnt2 ELISA Kit
 Kcnt2 Recombinant
 Kcnt2 Antibody
 Slick ELISA Kit
 Slick Recombinant
 Slick Antibody
Table BarTOPTable Bar
 

Potassium channel subfamily U member 1

 Potassium channel subfamily U member 1 ELISA Kit
 Potassium channel subfamily U member 1 Recombinant
 Potassium channel subfamily U member 1 Antibody
Also known as Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (KCa5) (Slowpoke homolog 3).
KCNU1: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Belongs to the
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potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: large conductance calcium-activated potassium channel activity; potassium channel activity; voltage-gated potassium channel activity

Biological Process: sperm-egg recognition
 KCNU1 ELISA Kit
 KCNU1 Recombinant
 KCNU1 Antibody
 KCNMA3 ELISA Kit
 KCNMA3 Recombinant
 KCNMA3 Antibody
 KCNMC1 ELISA Kit
 KCNMC1 Recombinant
 KCNMC1 Antibody
 SLO3 ELISA Kit
 SLO3 Recombinant
 SLO3 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
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