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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel

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Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

Below are the list of possible Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 ELISA Kit
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Recombinant
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Antibody
HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family.

Protein type: Membrane protein, integral; Membr
>>>
ane protein, multi-pass
 Hcn1 ELISA Kit
 Hcn1 Recombinant
 Hcn1 Antibody
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 ELISA Kit
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Recombinant
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Antibody
HCN2: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Belongs to the potassium channel HCN family. >>>
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Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: axon; cell soma; cytoplasm; dendritic shaft; integral to plasma membrane; membrane; plasma membrane; synapse

Molecular Function: identical protein binding; intracellular cAMP activated cation channel activity; PDZ domain binding; protein binding; protein complex binding; protein complex scaffold; voltage-gated potassium channel activity; voltage-gated sodium channel activity

Biological Process: aging; brain development; inflammatory response; positive regulation of heart contraction; regulation of membrane potential; response to drug; response to hormone stimulus
 Hcn2 ELISA Kit
 Hcn2 Recombinant
 Hcn2 Antibody
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 ELISA Kit
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Recombinant
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Antibody
HCN3: Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Belongs to the potassium channel HCN family.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Func
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tion: voltage-gated potassium channel activity; voltage-gated sodium channel activity

Biological Process: regulation of membrane potential
 HCN3 ELISA Kit
 HCN3 Recombinant
 HCN3 Antibody
 KIAA1535 ELISA Kit
 KIAA1535 Recombinant
 KIAA1535 Antibody
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Recombinant
 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Antibody
HCN4: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. Defects in HCN4 are a cause of sick sinus syndrome type 2 (SSS2); also known as atrial fibrillation with brady
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arrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder. Defects in HCN4 are the cause of Brugada syndrome type 8 (BRGDA8). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the potassium channel HCN family.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: integral to plasma membrane; intrinsic to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: identical protein binding; intracellular cAMP activated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity

Biological Process: cation transport; muscle contraction; regulation of heart rate; regulation of membrane potential

Disease: Brugada Syndrome 8; Sick Sinus Syndrome 2, Autosomal Dominant
 HCN4 ELISA Kit
 HCN4 Recombinant
 HCN4 Antibody
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