Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Potassium voltage-gated channel subfamily  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • SCN7A Antibody
 • Collagen Type II Alpha 1 (COL2A1) ELISA Kit
 • Elastin (ELN) ELISA Kit
 • PolioVirus Receptor Related Protein 1 (PVRL1) ELISA Kit
 • Phospho Spleen Tyosine Kinase (PHOSPHO-SYK) ELISA Kit
 • B-Lymphocyte Chemoattractant 1 (BLC1) ELISA Kit
 • C-Myc Oncogene Product ELISA Kit
 • Na-K-ATPase ELISA Kit
 • Tumor Type M2 Pyruvate Kinase (M2-PK) ELISA Kit
 • Soluble Amyloid Precursor Protein beta (SAPPbeta) ELISA Kit
 • Trypsin Antibody ELISA Kit
 • Matrix Extracellular Phosphoglycoprotein (MEPE) ELISA Kit
 • Soluble Interleukin-1 Receptor II (IL-1SR II) ELISA Kit
 • Keratin Growth Factor Receptor (KGFR) ELISA Kit
 downarrow more ...
separator

Potassium voltage-gated channel subfamily

separator
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability .

Below are the list of possible Potassium voltage-gated channel subfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Potassium voltage-gated channel subfamily A member 1

 Potassium voltage-gated channel subfamily A member 1 ELISA Kit
 Potassium voltage-gated channel subfamily A member 1 Recombinant
 Potassium voltage-gated channel subfamily A member 1 Antibody
Also known as Potassium voltage-gated channel subfamily A member 1 (MBK1) (MKI) (Voltage-gated potassium channel subunit Kv1.1).
Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may
>>>
pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; axon; cell junction; cell soma; cell surface; cytosol; dendrite; endoplasmic reticulum; integral to plasma membrane; nerve terminal; paranode region of axon; presynaptic membrane; synapse; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity

Biological Process: brain development; detection of mechanical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of touch; generation of action potential; hippocampus development; neuroblast proliferation; neuromuscular process; regulation of membrane potential; regulation of muscle contraction; startle response
 Kcna1 ELISA Kit
 Kcna1 Recombinant
 Kcna1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 10

 Potassium voltage-gated channel subfamily A member 10 ELISA Kit
 Potassium voltage-gated channel subfamily A member 10 Recombinant
 Potassium voltage-gated channel subfamily A member 10 Antibody
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP ().
 KCNA10 ELISA Kit
 KCNA10 Recombinant
 KCNA10 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 2

 Potassium voltage-gated channel subfamily A member 2 ELISA Kit
 Potassium voltage-gated channel subfamily A member 2 Recombinant
 Potassium voltage-gated channel subfamily A member 2 Antibody
Also known as Potassium voltage-gated channel subfamily A member 2 (CSMK1) (Voltage-gated potassium channel subunit Kv1.2).
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Fo
>>>
rms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8415758). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:8415758). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep ().
 KCNA2 ELISA Kit
 KCNA2 Recombinant
 KCNA2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 3

 Potassium voltage-gated channel subfamily A member 3 ELISA Kit
 Potassium voltage-gated channel subfamily A member 3 Recombinant
 Potassium voltage-gated channel subfamily A member 3 Antibody
Also known as Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3).
Kv1.3: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selec
>>>
tive channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: plasma membrane

Molecular Function: delayed rectifier potassium channel activity; voltage-gated ion channel activity

Biological Process: potassium ion transport
 KCNA3 ELISA Kit
 KCNA3 Recombinant
 KCNA3 Antibody
 HGK5 ELISA Kit
 HGK5 Recombinant
 HGK5 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 4

 Potassium voltage-gated channel subfamily A member 4 ELISA Kit
 Potassium voltage-gated channel subfamily A member 4 Recombinant
 Potassium voltage-gated channel subfamily A member 4 Antibody
Also known as Potassium voltage-gated channel subfamily A member 4 (BAK4) (Voltage-gated potassium channel subunit Kv1.4).
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened a
>>>
nd closed conformations in response to the voltage difference across the membrane (PubMed:1505668). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation ().
 KCNA4 ELISA Kit
 KCNA4 Recombinant
 KCNA4 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 5

 Potassium voltage-gated channel subfamily A member 5 ELISA Kit
 Potassium voltage-gated channel subfamily A member 5 Recombinant
 Potassium voltage-gated channel subfamily A member 5 Antibody
Also known as Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5).
Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel
>>>
through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: caveola; Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane; voltage-gated potassium channel complex

Molecular Function: alpha-actinin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein binding; protein kinase binding

Biological Process: membrane hyperpolarization; potassium ion transport; regulation of insulin secretion; regulation of membrane potential; regulation of potassium ion transport

Disease: Atrial Fibrillation, Familial, 7
 KCNA5 ELISA Kit
 KCNA5 Recombinant
 KCNA5 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 6

 Potassium voltage-gated channel subfamily A member 6 ELISA Kit
 Potassium voltage-gated channel subfamily A member 6 Recombinant
 Potassium voltage-gated channel subfamily A member 6 Antibody
Also known as Potassium voltage-gated channel subfamily A member 6 (MK1.6) (Voltage-gated potassium channel subunit Kv1.6).
Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass
>>>
in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: axon; integral to membrane; integral to plasma membrane; nerve terminal; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity
 Kcna6 ELISA Kit
 Kcna6 Recombinant
 Kcna6 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily A member 7

 Potassium voltage-gated channel subfamily A member 7 ELISA Kit
 Potassium voltage-gated channel subfamily A member 7 Recombinant
 Potassium voltage-gated channel subfamily A member 7 Antibody
Also known as Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7).
Kv1.7: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in acco
>>>
rdance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.

Protein type: Membrane protein, multi-pass

Cellular Component: integral to membrane

Molecular Function: delayed rectifier potassium channel activity
 Kcna7 ELISA Kit
 Kcna7 Recombinant
 Kcna7 Antibody
 Kcnc7 ELISA Kit
 Kcnc7 Recombinant
 Kcnc7 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily B member 1

 Potassium voltage-gated channel subfamily B member 1 ELISA Kit
 Potassium voltage-gated channel subfamily B member 1 Recombinant
 Potassium voltage-gated channel subfamily B member 1 Antibody
Also known as Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1).
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membra
>>>
ne, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: axon; dendrite; perikaryon; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; protein binding; protein heterodimerization activity; small conjugating protein binding

Biological Process: cellular response to nutrient levels; glucose homeostasis; glutamate signaling pathway; negative regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; regulation of action potential; regulation of insulin secretion; vesicle docking during exocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 26
 KCNB1 ELISA Kit
 KCNB1 Recombinant
 KCNB1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily B member 2

 Potassium voltage-gated channel subfamily B member 2 ELISA Kit
 Potassium voltage-gated channel subfamily B member 2 Recombinant
 Potassium voltage-gated channel subfamily B member 2 Antibody
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium
>>>
current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
 KCNB2 ELISA Kit
 KCNB2 Recombinant
 KCNB2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily C member 1

 Potassium voltage-gated channel subfamily C member 1 ELISA Kit
 Potassium voltage-gated channel subfamily C member 1 Recombinant
 Potassium voltage-gated channel subfamily C member 1 Antibody
Also known as Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4).
Kv3.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-sel
>>>
ective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: axolemma; cell soma; cell surface; dendrite; membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; kinesin binding; protein binding

Biological Process: brain development; cerebellum development; globus pallidus development; protein tetramerization; response to amine stimulus; response to light intensity; response to toxin
 Kcnc1 ELISA Kit
 Kcnc1 Recombinant
 Kcnc1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily C member 2

 Potassium voltage-gated channel subfamily C member 2 ELISA Kit
 Potassium voltage-gated channel subfamily C member 2 Recombinant
 Potassium voltage-gated channel subfamily C member 2 Antibody
Also known as Potassium voltage-gated channel subfamily C member 2 (Potassium channel voltage-gated Shaw-related subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel subunit Kv3.2).
KCNC2: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action
>>>
potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197, PubMed:10414303). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10482766, PubMed:14679187). Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (PubMed:11281123, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity)

Protein type: Membrane protein, integral; Membrane protein, multi-pass
 Kcnc2 ELISA Kit
 Kcnc2 Recombinant
 Kcnc2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily C member 3

 Potassium voltage-gated channel subfamily C member 3 ELISA Kit
 Potassium voltage-gated channel subfamily C member 3 Recombinant
 Potassium voltage-gated channel subfamily C member 3 Antibody
Also known as Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3).
transient voltage-dependent potassium channel [RGD, Feb 2006]
 Kcnc3 ELISA Kit
 Kcnc3 Recombinant
 Kcnc3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily C member 4

 Potassium voltage-gated channel subfamily C member 4 ELISA Kit
 Potassium voltage-gated channel subfamily C member 4 Recombinant
 Potassium voltage-gated channel subfamily C member 4 Antibody
Also known as Potassium voltage-gated channel subfamily C member 4 (KSHIIIC) (Voltage-gated potassium channel subunit Kv3.4).
Kv3.4: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassiu
>>>
m ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: plasma membrane

Molecular Function: delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; synaptic transmission
 KCNC4 ELISA Kit
 KCNC4 Recombinant
 KCNC4 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily D member 1

 Potassium voltage-gated channel subfamily D member 1 ELISA Kit
 Potassium voltage-gated channel subfamily D member 1 Recombinant
 Potassium voltage-gated channel subfamily D member 1 Antibody
Also known as Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
 KCND1 ELISA Kit
 KCND1 Recombinant
 KCND1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily D member 2

 Potassium voltage-gated channel subfamily D member 2 ELISA Kit
 Potassium voltage-gated channel subfamily D member 2 Recombinant
 Potassium voltage-gated channel subfamily D member 2 Antibody
Also known as Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2).
Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory
>>>
subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
 Kcnd2 ELISA Kit
 Kcnd2 Recombinant
 Kcnd2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily D member 3

 Potassium voltage-gated channel subfamily D member 3 ELISA Kit
 Potassium voltage-gated channel subfamily D member 3 Recombinant
 Potassium voltage-gated channel subfamily D member 3 Antibody
Also known as Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).
Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND
>>>
3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: A-type (transient outward) potassium channel activity; delayed rectifier potassium channel activity; protein binding

Biological Process: potassium ion transport

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
 KCND3 ELISA Kit
 KCND3 Recombinant
 KCND3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E member 1

 Potassium voltage-gated channel subfamily E member 1 ELISA Kit
 Potassium voltage-gated channel subfamily E member 1 Recombinant
 Potassium voltage-gated channel subfamily E member 1 Antibody
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activati
>>>
ng delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
 KCNE1 ELISA Kit
 KCNE1 Recombinant
 KCNE1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E member 1B

 Potassium voltage-gated channel subfamily E member 1B ELISA Kit
 Potassium voltage-gated channel subfamily E member 1B Recombinant
 Potassium voltage-gated channel subfamily E member 1B Antibody
KCNE1B: Belongs to the potassium channel KCNE family. {ECO:0000305}

Protein type: Membrane protein, integral
 KCNE1B ELISA Kit
 KCNE1B Recombinant
 KCNE1B Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E member 2

 Potassium voltage-gated channel subfamily E member 2 ELISA Kit
 Potassium voltage-gated channel subfamily E member 2 Recombinant
 Potassium voltage-gated channel subfamily E member 2 Antibody
Also known as Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1).
KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. A
>>>
ssociated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Cellular Component: cell surface; integral to membrane; lysosome; membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: cation channel activity; delayed rectifier potassium channel activity; inward rectifier potassium channel activity; potassium channel regulator activity; protein binding; protein homodimerization activity; voltage-gated potassium channel activity

Biological Process: aging; potassium ion import; tongue development
 Kcne2 ELISA Kit
 Kcne2 Recombinant
 Kcne2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E member 3

 Potassium voltage-gated channel subfamily E member 3 ELISA Kit
 Potassium voltage-gated channel subfamily E member 3 Recombinant
 Potassium voltage-gated channel subfamily E member 3 Antibody
Also known as Potassium voltage-gated channel subfamily E member 3 (MinK-related peptide 2) (Minimum potassium ion channel-related peptide 2) (Potassium channel subunit beta MiRP2).
a regulator that is coexpressed with K+ channel KCNQ1 [RGD, Feb 2006]
 Kcne3 ELISA Kit
 Kcne3 Recombinant
 Kcne3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E member 4

 Potassium voltage-gated channel subfamily E member 4 ELISA Kit
 Potassium voltage-gated channel subfamily E member 4 Recombinant
 Potassium voltage-gated channel subfamily E member 4 Antibody
Also known as Potassium voltage-gated channel subfamily E member 4 (MinK-related peptide 3) (Minimum potassium ion channel-related peptide 3) (Potassium channel subunit beta MiRP3).
KCNE4: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. M
>>>
ay associate with KCNQ1/KVLTQ1 and inhibit potassium current. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36.1

Molecular Function: protein binding
 KCNE4 ELISA Kit
 KCNE4 Recombinant
 KCNE4 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily E regulatory beta subunit 5

 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 ELISA Kit
 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Recombinant
 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Antibody
Also known as Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein).
KCNE1L: Defects in KCNE1L are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein
>>>
, integral

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: potassium channel regulator activity; protein binding; voltage-gated potassium channel activity

Biological Process: cardiac muscle contraction; regulation of heart contraction
 KCNE5 ELISA Kit
 KCNE5 Recombinant
 KCNE5 Antibody
 AMMECR2 ELISA Kit
 AMMECR2 Recombinant
 AMMECR2 Antibody
 KCNE1L ELISA Kit
 KCNE1L Recombinant
 KCNE1L Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily F member 1

 Potassium voltage-gated channel subfamily F member 1 ELISA Kit
 Potassium voltage-gated channel subfamily F member 1 Recombinant
 Potassium voltage-gated channel subfamily F member 1 Antibody
Also known as Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1).
Kv5.1: Putative voltage-gated potassium channel. Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane

Molec
>>>
ular Function: delayed rectifier potassium channel activity
 Kcnf1 ELISA Kit
 Kcnf1 Recombinant
 Kcnf1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily G member 1

 Potassium voltage-gated channel subfamily G member 1 ELISA Kit
 Potassium voltage-gated channel subfamily G member 1 Recombinant
 Potassium voltage-gated channel subfamily G member 1 Antibody
Also known as Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1).
Kv6.1: Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily. 2 isoforms of the human protein are prod
>>>
uced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: intracellular membrane-bound organelle; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity

Biological Process: potassium ion transport
 Kcng1 ELISA Kit
 Kcng1 Recombinant
 Kcng1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily G member 2

 Potassium voltage-gated channel subfamily G member 2 ELISA Kit
 Potassium voltage-gated channel subfamily G member 2 Recombinant
 Potassium voltage-gated channel subfamily G member 2 Antibody
Also known as Potassium voltage-gated channel subfamily G member 2 (Cardiac potassium channel subunit) (Voltage-gated potassium channel subunit Kv6.2).
Kv6.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.

>>>
Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane

Molecular Function: delayed rectifier potassium channel activity
 Kcng2 ELISA Kit
 Kcng2 Recombinant
 Kcng2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily G member 3

 Potassium voltage-gated channel subfamily G member 3 ELISA Kit
 Potassium voltage-gated channel subfamily G member 3 Recombinant
 Potassium voltage-gated channel subfamily G member 3 Antibody
Also known as Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3).
KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
>>>
>Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum; integral to membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport
 Kcng3 ELISA Kit
 Kcng3 Recombinant
 Kcng3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily G member 4

 Potassium voltage-gated channel subfamily G member 4 ELISA Kit
 Potassium voltage-gated channel subfamily G member 4 Recombinant
 Potassium voltage-gated channel subfamily G member 4 Antibody
Also known as Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).
KCNG4: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. 2 isoforms of the human protein are produce
>>>
d by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity
 KCNG4 ELISA Kit
 KCNG4 Recombinant
 KCNG4 Antibody
 KCNG3 ELISA Kit
 KCNG3 Recombinant
 KCNG3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 1

 Potassium voltage-gated channel subfamily H member 1 ELISA Kit
 Potassium voltage-gated channel subfamily H member 1 Recombinant
 Potassium voltage-gated channel subfamily H member 1 Antibody
Also known as Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (bEAG) (Voltage-gated potassium channel subunit Kv10.1).
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation
>>>
of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) ().
 KCNH1 ELISA Kit
 KCNH1 Recombinant
 KCNH1 Antibody
 EAG ELISA Kit
 EAG Recombinant
 EAG Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 2

 Potassium voltage-gated channel subfamily H member 2 ELISA Kit
 Potassium voltage-gated channel subfamily H member 2 Recombinant
 Potassium voltage-gated channel subfamily H member 2 Antibody
Also known as Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1).
Kv11.1: the ether-a-go-go related gene is a pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel is associated with cardiac arrhythmias and rhythmic excitability of the pituitary. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the del
>>>
ayed rectifying potassium current in heart (IKr). The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with Kv11.2 and Kv11.3. Interacts with ALG10B. Heteromultimer with KCNE1 and KCNE2. Defects in Kv11.1 are the cause of long QT syndrome type 2 (LQT2), a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. Defects in Kv11.1 are the cause of short QT syndrome type 1 (SQT1), a heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: cell surface; perinuclear region of cytoplasm; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; identical protein binding; inward rectifier potassium channel activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; voltage-gated potassium channel activity

Biological Process: cardiac muscle contraction; potassium ion homeostasis; regulation of membrane potential; regulation of the rate of heart contraction by hormone

Disease: Long Qt Syndrome 2; Short Qt Syndrome 1
 KCNH2 ELISA Kit
 KCNH2 Recombinant
 KCNH2 Antibody
 ERG ELISA Kit
 ERG Recombinant
 ERG Antibody
 ERG1 ELISA Kit
 ERG1 Recombinant
 ERG1 Antibody
 HERG ELISA Kit
 HERG Recombinant
 HERG Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 3

 Potassium voltage-gated channel subfamily H member 3 ELISA Kit
 Potassium voltage-gated channel subfamily H member 3 Recombinant
 Potassium voltage-gated channel subfamily H member 3 Antibody
Also known as Potassium voltage-gated channel subfamily H member 3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Voltage-gated potassium channel subunit Kv12.2).
Kv12.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and s
>>>
ubunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; voltage-gated potassium channel activity

Biological Process: potassium ion transport; regulation of membrane potential
 KCNH3 ELISA Kit
 KCNH3 Recombinant
 KCNH3 Antibody
 KIAA1282 ELISA Kit
 KIAA1282 Recombinant
 KIAA1282 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 4

 Potassium voltage-gated channel subfamily H member 4 ELISA Kit
 Potassium voltage-gated channel subfamily H member 4 Recombinant
 Potassium voltage-gated channel subfamily H member 4 Antibody
Also known as Potassium voltage-gated channel subfamily H member 4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Voltage-gated potassium channel subunit Kv12.3).
Kv12.3: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP a
>>>
nd subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Biological Process: potassium ion transport; regulation of membrane potential
 KCNH4 ELISA Kit
 KCNH4 Recombinant
 KCNH4 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 5

 Potassium voltage-gated channel subfamily H member 5 ELISA Kit
 Potassium voltage-gated channel subfamily H member 5 Recombinant
 Potassium voltage-gated channel subfamily H member 5 Antibody
Also known as Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (Eag2) (Voltage-gated potassium channel subunit Kv10.2).
Kv10.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H
>>>
(Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell surface; integral to plasma membrane; intracellular

Molecular Function: protein heterodimerization activity; voltage-gated potassium channel activity

Biological Process: regulation of G2/M transition of mitotic cell cycle; regulation of membrane potential
 Kcnh5 ELISA Kit
 Kcnh5 Recombinant
 Kcnh5 Antibody
 Eag2 ELISA Kit
 Eag2 Recombinant
 Eag2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 6

 Potassium voltage-gated channel subfamily H member 6 ELISA Kit
 Potassium voltage-gated channel subfamily H member 6 Recombinant
 Potassium voltage-gated channel subfamily H member 6 Antibody
Also known as Potassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Voltage-gated potassium channel subunit Kv11.2).
Kv11.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be
>>>
modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity

Biological Process: regulation of membrane potential
 KCNH6 ELISA Kit
 KCNH6 Recombinant
 KCNH6 Antibody
 ERG2 ELISA Kit
 ERG2 Recombinant
 ERG2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 7

 Potassium voltage-gated channel subfamily H member 7 ELISA Kit
 Potassium voltage-gated channel subfamily H member 7 Recombinant
 Potassium voltage-gated channel subfamily H member 7 Antibody
Also known as Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3).
Kv11.3: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the po
>>>
tassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity

Biological Process: regulation of membrane potential
 KCNH7 ELISA Kit
 KCNH7 Recombinant
 KCNH7 Antibody
 ERG3 ELISA Kit
 ERG3 Recombinant
 ERG3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily H member 8

 Potassium voltage-gated channel subfamily H member 8 ELISA Kit
 Potassium voltage-gated channel subfamily H member 8 Recombinant
 Potassium voltage-gated channel subfamily H member 8 Antibody
Also known as Potassium voltage-gated channel subfamily H member 8 (ELK1) (hElk1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1).
KCNH8: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belong
>>>
s to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p24.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity

Biological Process: regulation of membrane potential
 KCNH8 ELISA Kit
 KCNH8 Recombinant
 KCNH8 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily KQT member 1

 Potassium voltage-gated channel subfamily KQT member 1 ELISA Kit
 Potassium voltage-gated channel subfamily KQT member 1 Recombinant
 Potassium voltage-gated channel subfamily KQT member 1 Antibody
Also known as Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1).
Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (). Associates with KCNE beta subunits that modulates current kinetics ().
>>>
Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (). When associated with KCNE4, inhibits voltage-gated potassium channel activity (). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (). Binds with phosphatidylinositol 4,5-bisphosphate ().
 KCNQ1 ELISA Kit
 KCNQ1 Recombinant
 KCNQ1 Antibody
 KVLQT1 ELISA Kit
 KVLQT1 Recombinant
 KVLQT1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily KQT member 2

 Potassium voltage-gated channel subfamily KQT member 2 ELISA Kit
 Potassium voltage-gated channel subfamily KQT member 2 Recombinant
 Potassium voltage-gated channel subfamily KQT member 2 Antibody
Also known as Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2).
Kv7.2: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-curre
>>>
nt, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors. Defects in KCNQ2 are the cause of benign familial neonatal seizures type 1 (BFNS1). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet- discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia. Defects in KCNQ2 are the cause of epileptic encephalopathy early infantile type 7 (EIEE7). EIEE7 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: plasma membrane

Molecular Function: ankyrin binding; delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity

Biological Process: nervous system development; potassium ion transport; synaptic transmission

Disease: Epileptic Encephalopathy, Early Infantile, 7; Seizures, Benign Familial Neonatal, 1
 KCNQ2 ELISA Kit
 KCNQ2 Recombinant
 KCNQ2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily KQT member 3

 Potassium voltage-gated channel subfamily KQT member 3 ELISA Kit
 Potassium voltage-gated channel subfamily KQT member 3 Recombinant
 Potassium voltage-gated channel subfamily KQT member 3 Antibody
Also known as Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3).
Kv7.3: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly a
>>>
ctivating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell soma; cell surface; dendrite; lipid raft; neuron projection; plasma membrane; voltage-gated potassium channel complex

Molecular Function: calmodulin binding; delayed rectifier potassium channel activity; potassium channel activity; protein kinase binding; ubiquitin protein ligase binding; voltage-gated ion channel activity

Biological Process: membrane hyperpolarization
 Kcnq3 ELISA Kit
 Kcnq3 Recombinant
 Kcnq3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily KQT member 4

 Potassium voltage-gated channel subfamily KQT member 4 ELISA Kit
 Potassium voltage-gated channel subfamily KQT member 4 Recombinant
 Potassium voltage-gated channel subfamily KQT member 4 Antibody
Also known as Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4).
KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 a
>>>
nd bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cytoplasm; neuron projection; plasma membrane

Molecular Function: potassium channel activity; voltage-gated potassium channel activity

Biological Process: inner ear morphogenesis; negative regulation of synaptic transmission, dopaminergic; potassium ion transport; sensory perception of sound
 Kcnq4 ELISA Kit
 Kcnq4 Recombinant
 Kcnq4 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily KQT member 5

 Potassium voltage-gated channel subfamily KQT member 5 ELISA Kit
 Potassium voltage-gated channel subfamily KQT member 5 Recombinant
 Potassium voltage-gated channel subfamily KQT member 5 Antibody
Also known as Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5).
Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which pla
>>>
ys a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: clathrin coat; integral to membrane

Molecular Function: delayed rectifier potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport
 Kcnq5 ELISA Kit
 Kcnq5 Recombinant
 Kcnq5 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily S member 1

 Potassium voltage-gated channel subfamily S member 1 ELISA Kit
 Potassium voltage-gated channel subfamily S member 1 Recombinant
 Potassium voltage-gated channel subfamily S member 1 Antibody
Also known as Potassium voltage-gated channel subfamily S member 1 (Delayed-rectifier K(+) channel alpha subunit 1).
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
 KCNS1 ELISA Kit
 KCNS1 Recombinant
 KCNS1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily S member 2

 Potassium voltage-gated channel subfamily S member 2 ELISA Kit
 Potassium voltage-gated channel subfamily S member 2 Recombinant
 Potassium voltage-gated channel subfamily S member 2 Antibody
Also known as Potassium voltage-gated channel subfamily S member 2 (Delayed-rectifier K(+) channel alpha subunit 2) (Voltage-gated potassium channel subunit Kv9.2).
human homolog is a alpha subunit of a delayed-rectifier potassium channel [RGD, Feb 2006]
 Kcns2 ELISA Kit
 Kcns2 Recombinant
 Kcns2 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily S member 3

 Potassium voltage-gated channel subfamily S member 3 ELISA Kit
 Potassium voltage-gated channel subfamily S member 3 Recombinant
 Potassium voltage-gated channel subfamily S member 3 Antibody
Also known as Potassium voltage-gated channel subfamily S member 3 (Delayed-rectifier K(+) channel alpha subunit 3) (Voltage-gated potassium channel subunit Kv9.3).
delayed-rectifier potassium channel alpha subunit [RGD, Feb 2006]
 Kcns3 ELISA Kit
 Kcns3 Recombinant
 Kcns3 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily V member 1

 Potassium voltage-gated channel subfamily V member 1 ELISA Kit
 Potassium voltage-gated channel subfamily V member 1 Recombinant
 Potassium voltage-gated channel subfamily V member 1 Antibody
Also known as Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel alpha subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1).
KCNV1: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation.
>>>
Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q23.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; ion channel inhibitor activity; potassium channel regulator activity

Biological Process: potassium ion transport
 KCNV1 ELISA Kit
 KCNV1 Recombinant
 KCNV1 Antibody
Table BarTOPTable Bar
 

Potassium voltage-gated channel subfamily V member 2

 Potassium voltage-gated channel subfamily V member 2 ELISA Kit
 Potassium voltage-gated channel subfamily V member 2 Recombinant
 Potassium voltage-gated channel subfamily V member 2 Antibody
Also known as Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).
Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal
>>>
rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane

Molecular Function: delayed rectifier potassium channel activity
 Kcnv2 ELISA Kit
 Kcnv2 Recombinant
 Kcnv2 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions