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POU domain, class 5, transcription factor

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Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Below are the list of possible POU domain, class 5, transcription factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

POU domain, class 5, transcription factor 1

 POU domain, class 5, transcription factor 1 ELISA Kit
 POU domain, class 5, transcription factor 1 Recombinant
 POU domain, class 5, transcription factor 1 Antibody
Also known as POU domain, class 5, transcription factor 1 (NF-A3) (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3).
Oct4: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as
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YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleolus; nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex

Molecular Function: chromatin binding; chromatin DNA binding; cytokine binding; DNA binding; miRNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; transcription factor binding; ubiquitin protein ligase binding

Biological Process: blastocyst development; blastocyst growth; cell fate commitment; ectodermal cell fate commitment; endodermal cell fate commitment; endodermal cell fate specification; germ-line stem cell maintenance; mesodermal cell fate commitment; mRNA transcription from RNA polymerase II promoter; negative regulation of calcium ion-dependent exocytosis; negative regulation of cell differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of asymmetric cell division; regulation of gene expression; regulation of transcription, DNA-dependent; response to organic substance; response to retinoic acid; somatic stem cell maintenance; stem cell differentiation; stem cell maintenance; transcription from RNA polymerase II promoter; trophectodermal cell differentiation
 Pou5f1 ELISA Kit
 Pou5f1 Recombinant
 Pou5f1 Antibody
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POU domain, class 5, transcription factor 1.1

 POU domain, class 5, transcription factor 1.1 ELISA Kit
 POU domain, class 5, transcription factor 1.1 Recombinant
 POU domain, class 5, transcription factor 1.1 Antibody
Also known as POU domain, class 5, transcription factor 1.1 (POU class V protein oct-25).
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Activates transcription when directly bound to the octamer DNA sequence, but can form repression complexes with other proteins at the promoter site to inhibit transcription. Binds to the promoter of the vent2-B gene to activate transcri
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ption when in the presence of other BMP signaling factors also bound to the promoter. Inhibits the competence of ectodermal cells to respond to BMP during embryogenesis thereby inhibiting epidermal differentiation and promoting neural induction. Antagonizes the activity of nodal/activin signaling by forming a transcriptional repression complex on the gsc and mix2 gene promoters to inhibit their transcription, and thus maintain the undifferentiated state of embryonic cells to prevent them from differentiating prematurely. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription by forming a transcriptional repression complex on the nodal/nr1 and siamois promoters to inhibit their transcription ().
 pou5f1.1 ELISA Kit
 pou5f1.1 Recombinant
 pou5f1.1 Antibody
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POU domain, class 5, transcription factor 1.2

 POU domain, class 5, transcription factor 1.2 ELISA Kit
 POU domain, class 5, transcription factor 1.2 Recombinant
 POU domain, class 5, transcription factor 1.2 Antibody
Also known as POU domain, class 5, transcription factor 1.2 (POU class V protein oct-91) (XlPOU91) (Xoct-91).
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation.
 pou5f1.2 ELISA Kit
 pou5f1.2 Recombinant
 pou5f1.2 Antibody
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POU domain, class 5, transcription factor 1.3

 POU domain, class 5, transcription factor 1.3 ELISA Kit
 POU domain, class 5, transcription factor 1.3 Recombinant
 POU domain, class 5, transcription factor 1.3 Antibody
Also known as POU domain, class 5, transcription factor 1.3 (POU class V protein oct-60).
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression c
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omplex on the promoters of target genes. Binds to an octamer motif in interspersed RNA ().
 pou5f1.3 ELISA Kit
 pou5f1.3 Recombinant
 pou5f1.3 Antibody
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POU domain, class 5, transcription factor 2

 POU domain, class 5, transcription factor 2 ELISA Kit
 POU domain, class 5, transcription factor 2 Recombinant
 POU domain, class 5, transcription factor 2 Antibody
Also known as POU domain, class 5, transcription factor 2 (Sperm 1 POU domain transcription factor) (SPRM-1).
Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell.
 Pou5f2 ELISA Kit
 Pou5f2 Recombinant
 Pou5f2 Antibody
 Sprm1 ELISA Kit
 Sprm1 Recombinant
 Sprm1 Antibody
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POU domain, class 5, transcription factor 3

 POU domain, class 5, transcription factor 3 ELISA Kit
 POU domain, class 5, transcription factor 3 Recombinant
 POU domain, class 5, transcription factor 3 Antibody
Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'.
 POU5F3 ELISA Kit
 POU5F3 Recombinant
 POU5F3 Antibody
 POU2 ELISA Kit
 POU2 Recombinant
 POU2 Antibody
 POUV ELISA Kit
 POUV Recombinant
 POUV Antibody
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