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PR domain zinc finger protein

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Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs .

Below are the list of possible PR domain zinc finger protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PR domain zinc finger protein 1

 PR domain zinc finger protein 1 ELISA Kit
 PR domain zinc finger protein 1 Recombinant
 PR domain zinc finger protein 1 Antibody
Also known as PR domain zinc finger protein 1 (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1).
PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromati
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n-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nucleus

Molecular Function: histone deacetylase binding; protein binding; sequence-specific DNA binding

Biological Process: artery morphogenesis; cell fate commitment; embryonic placenta development; eye photoreceptor cell development; germ cell development; in utero embryonic development; maternal placenta development; morphogenesis of a branching structure; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell differentiation; post-embryonic development; regulation of cell proliferation; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation
 Prdm1 ELISA Kit
 Prdm1 Recombinant
 Prdm1 Antibody
 Blimp1 ELISA Kit
 Blimp1 Recombinant
 Blimp1 Antibody
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PR domain zinc finger protein 10

 PR domain zinc finger protein 10 ELISA Kit
 PR domain zinc finger protein 10 Recombinant
 PR domain zinc finger protein 10 Antibody
Also known as PR domain zinc finger protein 10 (PR domain-containing protein 10).
May be involved in transcriptional regulation.
 PRDM10 ELISA Kit
 PRDM10 Recombinant
 PRDM10 Antibody
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PR domain zinc finger protein 12

 PR domain zinc finger protein 12 ELISA Kit
 PR domain zinc finger protein 12 Recombinant
 PR domain zinc finger protein 12 Antibody
Also known as PR domain zinc finger protein 12 (PR domain-containing protein 12).
PRDM12: May be involved in transcriptional regulation.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted

Cellular Component: nucleus

Biological Process: detection of temperature stimulus involved in sensory perception of pain; neurite development; neurog
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enesis; positive regulation of histone H3-K9 methylation; sensory perception of pain
 Prdm12 ELISA Kit
 Prdm12 Recombinant
 Prdm12 Antibody
 Gm998 ELISA Kit
 Gm998 Recombinant
 Gm998 Antibody
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PR domain zinc finger protein 13

 PR domain zinc finger protein 13 ELISA Kit
 PR domain zinc finger protein 13 Recombinant
 PR domain zinc finger protein 13 Antibody
Also known as PR domain zinc finger protein 13 (PR domain-containing protein 13).
PRDM13: May be involved in transcriptional regulation.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted

Chromosomal Location of Human Ortholog: 6q16.2
 PRDM13 ELISA Kit
 PRDM13 Recombinant
 PRDM13 Antibody
 PFM10 ELISA Kit
 PFM10 Recombinant
 PFM10 Antibody
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PR domain zinc finger protein 14

 PR domain zinc finger protein 14 ELISA Kit
 PR domain zinc finger protein 14 Recombinant
 PR domain zinc finger protein 14 Antibody
Also known as PR domain zinc finger protein 14 (PR domain-containing protein 14).
PRDM14: a probable protein lysine methyltransferase that works in concert with the core human embryonic stem cell (ESC) regulators to control pluripotency associated genes. Binds to silenced genes in human ESCs. Its binding profile is enriched for the repressive tri-methylation of histone H3 lysine 27 (H3K27me3) m
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odification. Interacts directly with the polycomb repressive complex 2 (PRC2). PRC2 is detected at PRDM14-bound loci in human ESCs. A probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. Has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein arginine, predicted

Cellular Component: nucleus

Molecular Function: chromatin DNA binding; protein binding; RNA binding

Biological Process: cell fate specification; cell morphogenesis; embryo implantation; fertilization; germ cell development; germ-line stem cell maintenance; homeostasis of number of cells within a tissue; inner cell mass cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression; regulation of gene expression, epigenetic; stem cell maintenance
 Prdm14 ELISA Kit
 Prdm14 Recombinant
 Prdm14 Antibody
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PR domain zinc finger protein 15

 PR domain zinc finger protein 15 ELISA Kit
 PR domain zinc finger protein 15 Recombinant
 PR domain zinc finger protein 15 Antibody
Also known as PR domain zinc finger protein 15 (PR domain-containing protein 15) (Zinc finger protein 298).
PRDM15: May be involved in transcriptional regulation.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Transcription regulation

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleus

Molecular Function: transcription factor activity

Biological Process: regulation of transcription, DNA-dependent
 PRDM15 ELISA Kit
 PRDM15 Recombinant
 PRDM15 Antibody
 C21orf83 ELISA Kit
 C21orf83 Recombinant
 C21orf83 Antibody
 ZNF298 ELISA Kit
 ZNF298 Recombinant
 ZNF298 Antibody
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PR domain zinc finger protein 16

 PR domain zinc finger protein 16 ELISA Kit
 PR domain zinc finger protein 16 Recombinant
 PR domain zinc finger protein 16 Antibody
Also known as PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1).
PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precur
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sors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted

Cellular Component: nucleus; transcriptional repressor complex

Molecular Function: protein binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription coactivator activity

Biological Process: brown fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; somatic stem cell maintenance; stem cell maintenance; tongue development; white fat cell differentiation
 Prdm16 ELISA Kit
 Prdm16 Recombinant
 Prdm16 Antibody
 Kiaa1675 ELISA Kit
 Kiaa1675 Recombinant
 Kiaa1675 Antibody
 Mel1 ELISA Kit
 Mel1 Recombinant
 Mel1 Antibody
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PR domain zinc finger protein 2

 PR domain zinc finger protein 2 ELISA Kit
 PR domain zinc finger protein 2 Recombinant
 PR domain zinc finger protein 2 Antibody
Also known as PR domain zinc finger protein 2 (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ).
PRDM2: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. 3 isoforms of th
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e human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: nucleus
 PRDM2 ELISA Kit
 PRDM2 Recombinant
 PRDM2 Antibody
 KMT8 ELISA Kit
 KMT8 Recombinant
 KMT8 Antibody
 RIZ ELISA Kit
 RIZ Recombinant
 RIZ Antibody
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PR domain zinc finger protein 4

 PR domain zinc finger protein 4 ELISA Kit
 PR domain zinc finger protein 4 Recombinant
 PR domain zinc finger protein 4 Antibody
Also known as PR domain zinc finger protein 4 (PR domain-containing protein 4).
May function as a transcription factor involved in cell differentiation.
 PRDM4 ELISA Kit
 PRDM4 Recombinant
 PRDM4 Antibody
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PR domain zinc finger protein 5

 PR domain zinc finger protein 5 ELISA Kit
 PR domain zinc finger protein 5 Recombinant
 PR domain zinc finger protein 5 Antibody
Also known as PR domain zinc finger protein 5 (PR domain-containing protein 5).
PRDM5: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins i
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nvolved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription factor

Chromosomal Location of Human Ortholog: 4q25-q26

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: histone deacetylation; histone H3-K9 methylation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

Disease: Brittle Cornea Syndrome 2
 PRDM5 ELISA Kit
 PRDM5 Recombinant
 PRDM5 Antibody
 PFM2 ELISA Kit
 PFM2 Recombinant
 PFM2 Antibody
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PR domain zinc finger protein 8

 PR domain zinc finger protein 8 ELISA Kit
 PR domain zinc finger protein 8 Recombinant
 PR domain zinc finger protein 8 Antibody
Also known as PR domain zinc finger protein 8 (PR domain-containing protein 8).
PRDM8: May be involved in transcriptional regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: nucleus

Molecular Fun
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ction: protein binding

Biological Process: oligodendrocyte development

Disease: Epilepsy, Progressive Myoclonic, 10
 PRDM8 ELISA Kit
 PRDM8 Recombinant
 PRDM8 Antibody
 PFM5 ELISA Kit
 PFM5 Recombinant
 PFM5 Antibody
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