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Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs .
Below are the list of possible PR domain zinc finger protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. |
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PR domain zinc finger protein 1 ELISA Kit PR domain zinc finger protein 1 Recombinant PR domain zinc finger protein 1 Antibody | Also known as PR domain zinc finger protein 1 (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1). PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromati >>> n-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation; Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nucleus
Molecular Function: histone deacetylase binding; protein binding; sequence-specific DNA binding
Biological Process: artery morphogenesis; cell fate commitment; embryonic placenta development; eye photoreceptor cell development; germ cell development; in utero embryonic development; maternal placenta development; morphogenesis of a branching structure; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell differentiation; post-embryonic development; regulation of cell proliferation; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation |
Prdm1 ELISA Kit Prdm1 Recombinant Prdm1 Antibody | Blimp1 ELISA Kit Blimp1 Recombinant Blimp1 Antibody |
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PR domain zinc finger protein 14 ELISA Kit PR domain zinc finger protein 14 Recombinant PR domain zinc finger protein 14 Antibody | Also known as PR domain zinc finger protein 14 (PR domain-containing protein 14). PRDM14: a probable protein lysine methyltransferase that works in concert with the core human embryonic stem cell (ESC) regulators to control pluripotency associated genes. Binds to silenced genes in human ESCs. Its binding profile is enriched for the repressive tri-methylation of histone H3 lysine 27 (H3K27me3) m >>> odification. Interacts directly with the polycomb repressive complex 2 (PRC2). PRC2 is detected at PRDM14-bound loci in human ESCs. A probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. Has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Protein type: C2H2-type zinc finger protein; Methyltransferase, protein arginine, predicted
Cellular Component: nucleus
Molecular Function: chromatin DNA binding; protein binding; RNA binding
Biological Process: cell fate specification; cell morphogenesis; embryo implantation; fertilization; germ cell development; germ-line stem cell maintenance; homeostasis of number of cells within a tissue; inner cell mass cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression; regulation of gene expression, epigenetic; stem cell maintenance |
Prdm14 ELISA Kit Prdm14 Recombinant Prdm14 Antibody |
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PR domain zinc finger protein 16 ELISA Kit PR domain zinc finger protein 16 Recombinant PR domain zinc finger protein 16 Antibody | Also known as PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1). PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precur >>> sors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing
Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted
Cellular Component: nucleus; transcriptional repressor complex
Molecular Function: protein binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription coactivator activity
Biological Process: brown fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; somatic stem cell maintenance; stem cell maintenance; tongue development; white fat cell differentiation |
Prdm16 ELISA Kit Prdm16 Recombinant Prdm16 Antibody | Kiaa1675 ELISA Kit Kiaa1675 Recombinant Kiaa1675 Antibody |
Mel1 ELISA Kit Mel1 Recombinant Mel1 Antibody |
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PR domain zinc finger protein 5 ELISA Kit PR domain zinc finger protein 5 Recombinant PR domain zinc finger protein 5 Antibody | Also known as PR domain zinc finger protein 5 (PR domain-containing protein 5). PRDM5: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins i >>> nvolved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription factor
Chromosomal Location of Human Ortholog: 4q25-q26
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: histone deacetylation; histone H3-K9 methylation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Brittle Cornea Syndrome 2 |
PRDM5 ELISA Kit PRDM5 Recombinant PRDM5 Antibody | PFM2 ELISA Kit PFM2 Recombinant PFM2 Antibody |
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