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Pre-B-cell leukemia transcription factor

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Plays a role in the cAMP-dependent regulation of CYP17 gene expression via its cAMP-regulatory sequence (CRS1) 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression.

Below are the list of possible Pre-B-cell leukemia transcription factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Pre-B-cell leukemia transcription factor 1

 Pre-B-cell leukemia transcription factor 1 ELISA Kit
 Pre-B-cell leukemia transcription factor 1 Recombinant
 Pre-B-cell leukemia transcription factor 1 Antibody
Also known as Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1).
PBX1: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 whi
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ch binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor

Cellular Component: cytoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding

Biological Process: adrenal gland development; anterior/posterior pattern formation; embryonic hemopoiesis; embryonic limb morphogenesis; embryonic organ development; embryonic skeletal development; negative regulation of neuron differentiation; organ morphogenesis; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of cell proliferation; regulation of ossification; spleen development; thymus development; ureteric bud branching; urogenital system development
 Pbx1 ELISA Kit
 Pbx1 Recombinant
 Pbx1 Antibody
 Pbx-1 ELISA Kit
 Pbx-1 Recombinant
 Pbx-1 Antibody
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Pre-B-cell leukemia transcription factor 2

 Pre-B-cell leukemia transcription factor 2 ELISA Kit
 Pre-B-cell leukemia transcription factor 2 Recombinant
 Pre-B-cell leukemia transcription factor 2 Antibody
Also known as Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2).
PBX2: Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. Belongs to the TALE/PBX homeobox family.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleus; transcription factor complex

Molecular Function:
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chromatin binding; protein binding; transcription factor binding

Biological Process: embryonic limb morphogenesis; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation
 Pbx2 ELISA Kit
 Pbx2 Recombinant
 Pbx2 Antibody
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Pre-B-cell leukemia transcription factor 3

 Pre-B-cell leukemia transcription factor 3 ELISA Kit
 Pre-B-cell leukemia transcription factor 3 Recombinant
 Pre-B-cell leukemia transcription factor 3 Antibody
Also known as Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3).
PBX3: Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Belongs to the TALE/PBX homeobox family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q33.3

Biological Process: anterior compart
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ment specification; posterior compartment specification
 PBX3 ELISA Kit
 PBX3 Recombinant
 PBX3 Antibody
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Pre-B-cell leukemia transcription factor 4

 Pre-B-cell leukemia transcription factor 4 ELISA Kit
 Pre-B-cell leukemia transcription factor 4 Recombinant
 Pre-B-cell leukemia transcription factor 4 Antibody
Also known as Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4).
PBX4: a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but spec
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ific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Protein type: DNA-binding

Cellular Component: nucleus; XY body

Molecular Function: sequence-specific DNA binding

Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
 Pbx4 ELISA Kit
 Pbx4 Recombinant
 Pbx4 Antibody
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