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Pre-mRNA-processing-splicing factor

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Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.

Below are the list of possible Pre-mRNA-processing-splicing factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Pre-mRNA-processing-splicing factor 8

 Pre-mRNA-processing-splicing factor 8 ELISA Kit
 Pre-mRNA-processing-splicing factor 8 Recombinant
 Pre-mRNA-processing-splicing factor 8 Antibody
Also known as Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220).
PRPF8: Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes. Defects in PRPF8 are the
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cause of retinitis pigmentosa type 13 (RP13). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.

Protein type: RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: membrane; nucleoplasm; nucleus; snRNP U5

Molecular Function: protein binding; second spliceosomal transesterification activity; U1 snRNA binding; U2 snRNA binding; U5 snRNA binding; U6 snRNA binding

Biological Process: assembly of spliceosomal tri-snRNP; mRNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing; RNA splicing, via transesterification reactions

Disease: Retinitis Pigmentosa 13
 PRPF8 ELISA Kit
 PRPF8 Recombinant
 PRPF8 Antibody
 PRPC8 ELISA Kit
 PRPC8 Recombinant
 PRPC8 Antibody
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Pre-mRNA-processing-splicing factor 8 homolog

 Pre-mRNA-processing-splicing factor 8 homolog ELISA Kit
 Pre-mRNA-processing-splicing factor 8 homolog Recombinant
 Pre-mRNA-processing-splicing factor 8 homolog Antibody
Also known as Pre-mRNA-processing-splicing factor 8 homolog (Splicing factor Prp8).
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
 prpf8 ELISA Kit
 prpf8 Recombinant
 prpf8 Antibody
 prp8 ELISA Kit
 prp8 Recombinant
 prp8 Antibody
 DDB_G0274229 ELISA Kit
 DDB_G0274229 Recombinant
 DDB_G0274229 Antibody
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Pre-mRNA-processing-splicing factor 8A

 Pre-mRNA-processing-splicing factor 8A ELISA Kit
 Pre-mRNA-processing-splicing factor 8A Recombinant
 Pre-mRNA-processing-splicing factor 8A Antibody
Also known as Pre-mRNA-processing-splicing factor 8A (PRP8 homolog A) (AtPRP8A) (Protein ABNORMAL SUSPENSOR 2) (Protein EMBRYO DEFECTIVE 14) (Protein EMBRYO DEFECTIVE 177) (Protein EMBRYO DEFECTIVE 33) (Protein SUPPRESSOR OF OVEREXPRESSED FCA 81).
a genetic locus involved in embryogenesis. Mutations in this locus result in an abnormal suspensor and embryo lethality.
 PRP8A ELISA Kit
 PRP8A Recombinant
 PRP8A Antibody
 EMB14 ELISA Kit
 EMB14 Recombinant
 EMB14 Antibody
 EMB177 ELISA Kit
 EMB177 Recombinant
 EMB177 Antibody
 EMB33 ELISA Kit
 EMB33 Recombinant
 EMB33 Antibody
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Pre-mRNA-processing-splicing factor 8B

 Pre-mRNA-processing-splicing factor 8B ELISA Kit
 Pre-mRNA-processing-splicing factor 8B Recombinant
 Pre-mRNA-processing-splicing factor 8B Antibody
Also known as Pre-mRNA-processing-splicing factor 8B (PRP8 homolog B) (AtPRP8B).
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex.
 PRP8B ELISA Kit
 PRP8B Recombinant
 PRP8B Antibody
 At4g38780 ELISA Kit
 At4g38780 Recombinant
 At4g38780 Antibody
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