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Pregnancy zone protein

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Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Below are the list of possible Pregnancy zone protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Pregnancy zone protein

 Pregnancy zone protein ELISA Kit
 Pregnancy zone protein Recombinant
 Pregnancy zone protein Antibody
Also known as Pregnancy zone protein (Alpha-2-macroglobulin) (Alpha-2-M).
PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps t
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he proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular region

Molecular Function: brain-derived neurotrophic factor binding; endopeptidase inhibitor activity; nerve growth factor binding; protein complex binding

Biological Process: embryo implantation
 Pzp ELISA Kit
 Pzp Recombinant
 Pzp Antibody
 A2m ELISA Kit
 A2m Recombinant
 A2m Antibody
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