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PRKC apoptosis WT1 regulator protein

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Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).

Below are the list of possible PRKC apoptosis WT1 regulator protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

PRKC apoptosis WT1 regulator protein

 PRKC apoptosis WT1 regulator protein ELISA Kit
 PRKC apoptosis WT1 regulator protein Recombinant
 PRKC apoptosis WT1 regulator protein Antibody
Also known as PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4).
PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in ani
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mal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Protein type: Apoptosis

Cellular Component: actin cytoskeleton; actin filament; axon; cell soma; cytoplasm; neuron projection; nuclear chromatin; nucleus; plasma membrane

Molecular Function: actin binding; enzyme binding; leucine zipper domain binding; protein binding; protein kinase C binding; protein phosphatase 1 binding

Biological Process: actin filament bundle formation; apoptosis; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; interleukin-2 biosynthetic process; negative regulation of B cell proliferation; negative regulation of fibroblast proliferation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of action potential; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of phosphoprotein phosphatase activity
 Pawr ELISA Kit
 Pawr Recombinant
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 Par4 Recombinant
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