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Probable helicase senataxin

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Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation .

Below are the list of possible Probable helicase senataxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Probable helicase senataxin

 Probable helicase senataxin ELISA Kit
 Probable helicase senataxin Recombinant
 Probable helicase senataxin Antibody
Also known as Probable helicase senataxin (Amyotrophic lateral sclerosis 4 protein homolog) (SEN1 homolog).
senataxin: Probable helicase, which may be involved in RNA maturation. Involved in DNA double-strand breaks damage response generated by oxidative stress. Defects in SETX are the cause of spinocerebellar ataxia autosomal recessive type 1 (SCAR1); also known as ataxia-ocular apraxia 2. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye m
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ovements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR1 is an autosomal recessive form associated with peripheral neuropathy and elevated serum alpha- fetoprotein, immunoglobulins and, less commonly, creatine kinase levels. Some SCAR1 patients manifest oculomotor apraxia. Defects in SETX are a cause of amyotrophic lateral sclerosis type 4 (ALS4). ALS4 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. ALS4 is a childhood- or adolescent- onset form characterized by slow disease progression and the sparing of bulbar and respiratory muscles. Belongs to the DNA2/NAM7 helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; Nucleolus

Cellular Component: axon; cytoplasm; growth cone; nuclear chromosome; nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding

Biological Process: circadian rhythm; double-strand break repair; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; mRNA splice site selection; negative regulation of apoptosis; positive regulation of RNA splicing; positive regulation of transcription from RNA polymerase II promoter; protein kinase B signaling cascade; response to DNA damage stimulus; termination of RNA polymerase II transcription; transcription termination
 Setx ELISA Kit
 Setx Recombinant
 Setx Antibody
 Als4 ELISA Kit
 Als4 Recombinant
 Als4 Antibody
 Kiaa0625 ELISA Kit
 Kiaa0625 Recombinant
 Kiaa0625 Antibody
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