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Prokineticin

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Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).

Below are the list of possible Prokineticin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Prokineticin Bm8-a

 Prokineticin Bm8-a ELISA Kit
 Prokineticin Bm8-a Recombinant
 Prokineticin Bm8-a Antibody
Also known as Prokineticin Bm8-a (Prokineticin Bv8-like peptide 1) (Bv8-LP1).
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potent
>>>
iates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
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Prokineticin Bm8-b

 Prokineticin Bm8-b ELISA Kit
 Prokineticin Bm8-b Recombinant
 Prokineticin Bm8-b Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bm8-c

 Prokineticin Bm8-c ELISA Kit
 Prokineticin Bm8-c Recombinant
 Prokineticin Bm8-c Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bm8-d

 Prokineticin Bm8-d ELISA Kit
 Prokineticin Bm8-d Recombinant
 Prokineticin Bm8-d Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bm8-e

 Prokineticin Bm8-e ELISA Kit
 Prokineticin Bm8-e Recombinant
 Prokineticin Bm8-e Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bm8-f

 Prokineticin Bm8-f ELISA Kit
 Prokineticin Bm8-f Recombinant
 Prokineticin Bm8-f Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bo8

 Prokineticin Bo8 ELISA Kit
 Prokineticin Bo8 Recombinant
 Prokineticin Bo8 Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons. At subnanomola
>>>
r concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration).
Table BarTOPTable Bar
 

Prokineticin Bv8

 Prokineticin Bv8 ELISA Kit
 Prokineticin Bv8 Recombinant
 Prokineticin Bv8 Antibody
Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia (PubMed:16299550, PubMed:20677202). Shows an EC(50) of 0.264 nM, when tested on neuroblastoma
>>>
cells (SH-SY5Y) which endogenously express mainly PKR2/PROKR2 (PubMed:20677202). Also potentiates capsaicin-induced TRPV1 current, when tested on DRG neurons (PubMed:16687502, PubMed:20677202). Induces a biphasic hyperalgesia to tactile and thermal stimuli after systemic injection of this protein into rat (PubMed:10422759, PubMed:12466223). The initial phase of hyperalgesia is caused by a local action on nociceptors, because intraplantar injection of this protein causes a strong and localized hyperalgesia with a similar time course to that of the initial phase of hyperalgesia seen with systemic injection. The secondary phase of hyperalgesia is not seen with local intraplantar injection and is therefore probably attributable to a central action of this protein (PubMed:16687502). At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the proinflammatory cytokines IL-1 and IL-12 (PubMed:16299550). In vivo, this protein potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (at nanomolar concentration) (PubMed:10422759).
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Prokineticin-1

 Prokineticin-1 ELISA Kit
 Prokineticin-1 Recombinant
 Prokineticin-1 Antibody
Also known as Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF).
may act as an endothelial cell mitogen; may be involved in G-protein coupled receptor signaling via regulation of intracellular calcium [RGD, Feb 2006]
 Prok1 ELISA Kit
 Prok1 Recombinant
 Prok1 Antibody
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Prokineticin-2

 Prokineticin-2 ELISA Kit
 Prokineticin-2 Recombinant
 Prokineticin-2 Antibody
Also known as Prokineticin-2 (PK2).
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle ().
 PROK2 ELISA Kit
 PROK2 Recombinant
 PROK2 Antibody
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