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Proline-serine-threonine phosphatase-interacting protein

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Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Below are the list of possible Proline-serine-threonine phosphatase-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Proline-serine-threonine phosphatase-interacting protein 1

 Proline-serine-threonine phosphatase-interacting protein 1 ELISA Kit
 Proline-serine-threonine phosphatase-interacting protein 1 Recombinant
 Proline-serine-threonine phosphatase-interacting protein 1 Antibody
Also known as Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).
PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Componen
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t: cleavage furrow; contractile ring; membrane; stress fiber

Molecular Function: actin binding; protein binding; protein phosphatase binding

Biological Process: cytokinesis
 Pstpip1 ELISA Kit
 Pstpip1 Recombinant
 Pstpip1 Antibody
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Proline-serine-threonine phosphatase-interacting protein 2

 Proline-serine-threonine phosphatase-interacting protein 2 ELISA Kit
 Proline-serine-threonine phosphatase-interacting protein 2 Recombinant
 Proline-serine-threonine phosphatase-interacting protein 2 Antibody
Also known as Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2).
Binds to F-actin. May be involved in regulation of the actin cytoskeleton ().
 PSTPIP2 ELISA Kit
 PSTPIP2 Recombinant
 PSTPIP2 Antibody
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