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Prolow-density lipoprotein receptor-related protein

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.; Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Below are the list of possible Prolow-density lipoprotein receptor-related protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Prolow-density lipoprotein receptor-related protein 1

 Prolow-density lipoprotein receptor-related protein 1 ELISA Kit
 Prolow-density lipoprotein receptor-related protein 1 Recombinant
 Prolow-density lipoprotein receptor-related protein 1 Antibody
Also known as Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91).
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endog
enous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm; focal adhesion; integral to plasma membrane; lysosomal membrane; nucleolus; plasma membrane; receptor complex

Molecular Function: apolipoprotein binding; calcium ion binding; low-density lipoprotein receptor activity; protein binding; protein complex binding; receptor activity

Biological Process: apoptotic cell clearance; negative regulation of smooth muscle cell migration; negative regulation of Wnt receptor signaling pathway; positive regulation of lipid transport; receptor-mediated endocytosis; regulation of actin cytoskeleton organization and biogenesis; regulation of cholesterol transport; regulation of phospholipase A2 activity; retinoid metabolic process

Disease: Keratosis Pilaris Atrophicans
 LRP1 Recombinant
 LRP1 Antibody
 A2MR Recombinant
 A2MR Antibody
 APR Recombinant
 APR Antibody
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