| Prolow-density lipoprotein receptor-related protein 1 ELISA Kit|
Prolow-density lipoprotein receptor-related protein 1 Recombinant
Prolow-density lipoprotein receptor-related protein 1 Antibody
|Also known as Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91). |
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endog
enous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.
Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: cytoplasm; focal adhesion; integral to plasma membrane; lysosomal membrane; nucleolus; plasma membrane; receptor complex
Molecular Function: apolipoprotein binding; calcium ion binding; low-density lipoprotein receptor activity; protein binding; protein complex binding; receptor activity
Biological Process: apoptotic cell clearance; negative regulation of smooth muscle cell migration; negative regulation of Wnt receptor signaling pathway; positive regulation of lipid transport; receptor-mediated endocytosis; regulation of actin cytoskeleton organization and biogenesis; regulation of cholesterol transport; regulation of phospholipase A2 activity; retinoid metabolic process
Disease: Keratosis Pilaris Atrophicans
| LRP1 ELISA Kit|
| A2MR ELISA Kit|
| APR ELISA Kit|