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Prominin

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May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis . Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Below are the list of possible Prominin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Prominin-1

 Prominin-1 ELISA Kit
 Prominin-1 Recombinant
 Prominin-1 Antibody
Also known as Prominin-1 (Antigen AC133 homolog) (Prominin-like protein 1) (CD antigen CD133).
CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34
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hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; brush border; cell projection; cell surface; cilium; endoplasmic reticulum; ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; microvillus; photoreceptor outer segment; plasma membrane; stereocilium; vesicle

Molecular Function: actinin binding; cadherin binding

Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye
 Prom1 ELISA Kit
 Prom1 Recombinant
 Prom1 Antibody
 Prom ELISA Kit
 Prom Recombinant
 Prom Antibody
 Proml1 ELISA Kit
 Proml1 Recombinant
 Proml1 Antibody
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Prominin-1-A

 Prominin-1-A ELISA Kit
 Prominin-1-A Recombinant
 Prominin-1-A Antibody
Also known as Prominin-1-A (Prominin-like protein 1).
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. Involved in regulation of MAPK and Akt signaling pathways ().
 prom1a ELISA Kit
 prom1a Recombinant
 prom1a Antibody
 proml1 ELISA Kit
 proml1 Recombinant
 proml1 Antibody
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Prominin-2

 Prominin-2 ELISA Kit
 Prominin-2 Recombinant
 Prominin-2 Antibody
Also known as Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2).
PROM2: a multi-pass membrane protein of the prominin family that binds cholesterol. Localizes to the apical and basolateral membranes of epithelial cells. Present in saliva within small membrane particles. Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. Three alternatively spliced human isoforms have be
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en described.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: cell projection; cell surface; cilium; cytoplasmic vesicle; integral to plasma membrane; lipid raft; microvillus

Molecular Function: cholesterol binding

Biological Process: negative regulation of pinocytosis; positive regulation of cell projection organization and biogenesis; positive regulation of protein amino acid phosphorylation; regulation of GTPase activity
 PROM2 ELISA Kit
 PROM2 Recombinant
 PROM2 Antibody
 PROML2 ELISA Kit
 PROML2 Recombinant
 PROML2 Antibody
 UNQ2521/PRO6014 ELISA Kit
 UNQ2521/PRO6014 Recombinant
 UNQ2521/PRO6014 Antibody
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