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Proprotein convertase subtilisin/kexin

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Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida .

Below are the list of possible Proprotein convertase subtilisin/kexin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Proprotein convertase subtilisin/kexin type 4

 Proprotein convertase subtilisin/kexin type 4 ELISA Kit
 Proprotein convertase subtilisin/kexin type 4 Recombinant
 Proprotein convertase subtilisin/kexin type 4 Antibody
Also known as Proprotein convertase subtilisin/kexin type 4 (KEX2-like endoprotease 3) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3).
PCSK4: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 3.4.21.-; Membr
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ane protein, integral; Protease

Cellular Component: acrosomal membrane; acrosome; extracellular space

Molecular Function: serine-type endopeptidase activity

Biological Process: acrosome reaction; binding of sperm to zona pellucida; fertilization; protein processing; reproductive process; sperm capacitation
 Pcsk4 ELISA Kit
 Pcsk4 Recombinant
 Pcsk4 Antibody
 Nec-3 ELISA Kit
 Nec-3 Recombinant
 Nec-3 Antibody
 Nec3 ELISA Kit
 Nec3 Recombinant
 Nec3 Antibody
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Proprotein convertase subtilisin/kexin type 5

 Proprotein convertase subtilisin/kexin type 5 ELISA Kit
 Proprotein convertase subtilisin/kexin type 5 Recombinant
 Proprotein convertase subtilisin/kexin type 5 Antibody
Also known as Proprotein convertase subtilisin/kexin type 5 (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5).
PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein t
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ype: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 9q21.3

Cellular Component: extracellular space; Golgi apparatus; Golgi lumen; secretory granule

Molecular Function: peptidase activity; peptide binding; protein binding; serine-type endopeptidase activity

Biological Process: anterior/posterior pattern formation; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic gut development; embryonic skeletal development; heart development; kidney development; limb morphogenesis; nerve growth factor processing; peptide biosynthetic process; peptide hormone processing; protein processing; renin secretion into blood stream; respiratory tube development; signal peptide processing; viral infectious cycle
 PCSK5 ELISA Kit
 PCSK5 Recombinant
 PCSK5 Antibody
 PC5 ELISA Kit
 PC5 Recombinant
 PC5 Antibody
 PC6 ELISA Kit
 PC6 Recombinant
 PC6 Antibody
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Proprotein convertase subtilisin/kexin type 6

 Proprotein convertase subtilisin/kexin type 6 ELISA Kit
 Proprotein convertase subtilisin/kexin type 6 Recombinant
 Proprotein convertase subtilisin/kexin type 6 Antibody
Also known as Proprotein convertase subtilisin/kexin type 6 (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4).
PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of clea
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vage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cell surface; extracellular matrix; extracellular space; Golgi lumen

Molecular Function: endopeptidase activity; heparin binding; nerve growth factor binding; serine-type endopeptidase activity

Biological Process: glycoprotein metabolic process; nerve growth factor processing; nerve growth factor production; peptide hormone processing; protein processing; regulation of BMP signaling pathway; secretion by cell
 PCSK6 ELISA Kit
 PCSK6 Recombinant
 PCSK6 Antibody
 PACE4 ELISA Kit
 PACE4 Recombinant
 PACE4 Antibody
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Proprotein convertase subtilisin/kexin type 7

 Proprotein convertase subtilisin/kexin type 7 ELISA Kit
 Proprotein convertase subtilisin/kexin type 7 Recombinant
 Proprotein convertase subtilisin/kexin type 7 Antibody
Also known as Proprotein convertase subtilisin/kexin type 7 (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7).
PCSK7: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. Belongs to the peptidase S8 family.

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 11q23-q24

Cellular Component: integral to Golgi m
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embrane

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: protein processing
 PCSK7 ELISA Kit
 PCSK7 Recombinant
 PCSK7 Antibody
 LPC ELISA Kit
 LPC Recombinant
 LPC Antibody
 PC7 ELISA Kit
 PC7 Recombinant
 PC7 Antibody
 PC8 ELISA Kit
 PC8 Recombinant
 PC8 Antibody
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Proprotein convertase subtilisin/kexin type 9

 Proprotein convertase subtilisin/kexin type 9 ELISA Kit
 Proprotein convertase subtilisin/kexin type 9 Recombinant
 Proprotein convertase subtilisin/kexin type 9 Antibody
Also known as Proprotein convertase subtilisin/kexin type 9 (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9).
PCSK9: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance
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the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Defects in PCSK9 are the cause of hypercholesterolemia autosomal dominant type 3 (HCHOLA3). A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum; extracellular space; extrinsic to external side of plasma membrane; Golgi apparatus; late endosome; lysosome; perinuclear region of cytoplasm; plasma membrane

Molecular Function: apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein binding; low-density lipoprotein receptor binding; protein binding; protein self-association; receptor inhibitor activity; serine-type endopeptidase activity; sodium channel inhibitor activity; very-low-density lipoprotein binding

Biological Process: cellular response to insulin stimulus; cellular response to starvation; cholesterol homeostasis; kidney development; liver development; low-density lipoprotein receptor catabolic process; lysosomal transport; negative regulation of receptor recycling; neurogenesis; neuron differentiation; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of neuron apoptosis; positive regulation of receptor internalization; protein autoprocessing; regulation of neuron apoptosis; regulation of receptor activity

Disease: Hypercholesterolemia, Autosomal Dominant, 3
 PCSK9 ELISA Kit
 PCSK9 Recombinant
 PCSK9 Antibody
 NARC1 ELISA Kit
 NARC1 Recombinant
 NARC1 Antibody
 PSEC0052 ELISA Kit
 PSEC0052 Recombinant
 PSEC0052 Antibody
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