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Prostaglandin-H2 D-isomerase

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Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Below are the list of possible Prostaglandin-H2 D-isomerase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Prostaglandin-H2 D-isomerase

 Prostaglandin-H2 D-isomerase ELISA Kit
 Prostaglandin-H2 D-isomerase Recombinant
 Prostaglandin-H2 D-isomerase Antibody
Also known as Prostaglandin-H2 D-isomerase (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2).
PTGDS: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a va
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riety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Belongs to the calycin superfamily. Lipocalin family.

Protein type: EC 5.3.99.2; Endoplasmic reticulum; Isomerase; Lipid Metabolism - arachidonic acid; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34.2-q34.3

Cellular Component: endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi apparatus; rough endoplasmic reticulum

Molecular Function: fatty acid binding; prostaglandin-D synthase activity; protein binding; retinoid binding; transporter activity

Biological Process: cyclooxygenase pathway; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep; transport
 PTGDS ELISA Kit
 PTGDS Recombinant
 PTGDS Antibody
 PDS ELISA Kit
 PDS Recombinant
 PDS Antibody
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