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Protein bassoon

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Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses (By similarity). Involved in the formation of the retinal photoreceptor ribbon synapses.

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Protein bassoon

 Protein bassoon ELISA Kit
 Protein bassoon Recombinant
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BSN: involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Interacts with CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Local
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ized to the active zone of presynaptic density. Mice lacking functional BSN showed a reduced excitability attributed to inactivation of a fraction of brain glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers, but are unable to fuse. In retina, mutants lacking functional BSN showed normal retinal anatomy, but synapses lacked anchoring of the photoreceptor ribbon to the presynaptic active zone resulting in impaired photoreceptor synaptic transmission. Two alternatively spliced isoforms have been reported.

Protein type: Cytoskeletal

Cellular Component: axon; cell soma; cell surface; dendrite; excitatory synapse; extrinsic to membrane; integral to membrane; postsynaptic density; presynaptic active zone; synapse; trans-Golgi network

Molecular Function: protein binding
 Bsn ELISA Kit
 Bsn Recombinant
 Bsn Antibody
 Kiaa0434 ELISA Kit
 Kiaa0434 Recombinant
 Kiaa0434 Antibody
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