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Protein cereblon

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Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.

Below are the list of possible Protein cereblon products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Protein cereblon

 Protein cereblon ELISA Kit
 Protein cereblon Recombinant
 Protein cereblon Antibody
CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activ
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ated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of protein homooligomerization; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination
 Crbn ELISA Kit
 Crbn Recombinant
 Crbn Antibody
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Protein cereblon homolog

 Protein cereblon homolog ELISA Kit
 Protein cereblon homolog Recombinant
 Protein cereblon homolog Antibody
 GL27201 ELISA Kit
 GL27201 Recombinant
 GL27201 Antibody
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Proteins Root Name Listing
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