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Protein crumbs

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Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina.

Below are the list of possible Protein crumbs products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Protein crumbs

 Protein crumbs ELISA Kit
 Protein crumbs Recombinant
 Protein crumbs Antibody
Also known as Protein crumbs (95F).
Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, fo
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r positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina.
 crb ELISA Kit
 crb Recombinant
 crb Antibody
 CG6383 ELISA Kit
 CG6383 Recombinant
 CG6383 Antibody
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Protein crumbs homolog 1

 Protein crumbs homolog 1 ELISA Kit
 Protein crumbs homolog 1 Recombinant
 Protein crumbs homolog 1 Antibody
CRB1: Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. CRB1 mutations have been found in various retinal dystrophies, chronic and disabling disorders of visual function. They predominantly involve the posterior portion of the ocular fundus, due to degeneration in the sensory layer of the retina, retinal pigment epithelium, Bruch membrane, chor
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oid, or a combination of these tissues. Onset of inherited retinal dystrophies is painless, bilateral and typically progressive. Most people experience gradual peripheral vision loss or tunnel vision, and difficulties with poor illumination and night vision. Central vision is usually unaffected, so the person may still be able to read. However, it can also deteriorate to cause total blindness. Examples of retinal dystrophies are retinitis pigmentosa, Leber congenital amaurosis, cone-rod dystrophy among others. Defects in CRB1 are the cause of retinitis pigmentosa type 12 (RP12). A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells, followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP12 is an autosomal recessive severe form oFTen manifesting in early childhood. Patients experiment progressive visual field loss with severe visual impairment before the age of twenty. Some patients have a preserved paraarteriolar retinal pigment epithelium (PPRPE) and hypermetropia. Defects in CRB1 are the cause of Leber congenital amaurosis type 8 (LCA8). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in CRB1 are the cause of pigmented paravenous chorioretinal atrophy (PPCRA). PPCRA is an unusual retinal degeneration characterized by accumulation of pigmentation along retinal veins. PPCRA is dominantly inherited, but exhibited variable expressivity. Males are more likely to exhibit a severe phenotype, whereas females may remain virtually asymptomatic even in later years. The PPCRA phenotype is associated with a mutation in CRB1 gene which is likely to affect the structure of the CRB1 protein. Belongs to the Crumbs protein family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: microvillus; plasma membrane

Molecular Function: protein binding

Biological Process: eye photoreceptor cell development; plasma membrane organization and biogenesis
 Crb1 ELISA Kit
 Crb1 Recombinant
 Crb1 Antibody
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Protein crumbs homolog 2

 Protein crumbs homolog 2 ELISA Kit
 Protein crumbs homolog 2 Recombinant
 Protein crumbs homolog 2 Antibody
Also known as Protein crumbs homolog 2 (Crumbs-like protein 2).
CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: lipid raft
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; protein complex

Molecular Function: aspartic-type endopeptidase inhibitor activity; enzyme binding

Biological Process: maintenance of epithelial cell polarity; mesoderm formation; notochord formation; positive regulation of BMP signaling pathway; somitogenesis

Disease: Focal Segmental Glomerulosclerosis 9; Ventriculomegaly With Cystic Kidney Disease
 CRB2 ELISA Kit
 CRB2 Recombinant
 CRB2 Antibody
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Protein crumbs homolog 3

 Protein crumbs homolog 3 ELISA Kit
 Protein crumbs homolog 3 Recombinant
 Protein crumbs homolog 3 Antibody
CRB3: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; apical plasma membrane; protein complex

Biological
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Process: establishment of epithelial cell polarity; intercellular junction assembly and maintenance
 Crb3 ELISA Kit
 Crb3 Recombinant
 Crb3 Antibody
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