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Protein diaphanous

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Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.

Below are the list of possible Protein diaphanous products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Protein diaphanous

 Protein diaphanous ELISA Kit
 Protein diaphanous Recombinant
 Protein diaphanous Antibody
Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.
 dia ELISA Kit
 dia Recombinant
 dia Antibody
 CG1768 ELISA Kit
 CG1768 Recombinant
 CG1768 Antibody
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Protein diaphanous homolog 1

 Protein diaphanous homolog 1 ELISA Kit
 Protein diaphanous homolog 1 Recombinant
 Protein diaphanous homolog 1 Antibody
Also known as Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).
Diaphanous-1: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytok
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inesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Homodimer. Interacts with the GTP-bound form of RHOA. Interacts with RHOC, PFY1, MAPRE1, BAIAP2 and APC. Interacts with SCAI. Interacts with DCAF7, via FH2 domain. Interacts with NCDN. Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea. Belongs to the formin homology family. Diaphanous subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: cytoskeleton organization and biogenesis; regulation of cell shape; regulation of microtubule-based process; regulation of release of sequestered calcium ion into cytosol

Disease: Deafness, Autosomal Dominant 1; Seizures, Cortical Blindness, And Microcephaly Syndrome
 DIAPH1 ELISA Kit
 DIAPH1 Recombinant
 DIAPH1 Antibody
 DIAP1 ELISA Kit
 DIAP1 Recombinant
 DIAP1 Antibody
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Protein diaphanous homolog 2

 Protein diaphanous homolog 2 ELISA Kit
 Protein diaphanous homolog 2 Recombinant
 Protein diaphanous homolog 2 Antibody
Also known as Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).
Diaphanous-2: Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Isoform 3 inte
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racts with RHOD in the GTP-bound form. Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. Belongs to the formin homology family. Diaphanous subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq21.33

Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleolus

Molecular Function: receptor binding

Biological Process: cytokinesis; female gamete generation

Disease: Premature Ovarian Failure 2a
 DIAPH2 ELISA Kit
 DIAPH2 Recombinant
 DIAPH2 Antibody
 DIA ELISA Kit
 DIA Recombinant
 DIA Antibody
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Protein diaphanous homolog 3

 Protein diaphanous homolog 3 ELISA Kit
 Protein diaphanous homolog 3 Recombinant
 Protein diaphanous homolog 3 Antibody
Also known as Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2).
Diaphanous-3: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple R
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ho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Defects in DIAPH3 are the cause of auditory neuropathy, autosomal dominant, type 1 (AUNA1). A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem. A disease- causing mutation in the conserved 5'-UTR leads to increased protein expression (PubMed:20624953). Belongs to the formin homology family. Diaphanous subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q21.2

Cellular Component: cell-cell adherens junction; cytosol

Disease: Auditory Neuropathy, Autosomal Dominant, 1
 DIAPH3 ELISA Kit
 DIAPH3 Recombinant
 DIAPH3 Antibody
 DIAP3 ELISA Kit
 DIAP3 Recombinant
 DIAP3 Antibody
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