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Protein regulator of cytokinesis

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Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.

Below are the list of possible Protein regulator of cytokinesis products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Protein regulator of cytokinesis 1

 Protein regulator of cytokinesis 1 ELISA Kit
 Protein regulator of cytokinesis 1 Recombinant
 Protein regulator of cytokinesis 1 Antibody
PRC1: translocates to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Acts as a microtubule-binding and bundling protein both in vivo and vitro. Interacts with the C-terminal Rho-GAP domain and the basic region of MgcRacGAP. The
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interaction with MgcRacGAP inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis.

Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; plasma membrane; spindle

Molecular Function: kinesin binding; protein kinase binding

Biological Process: cytokinesis; positive regulation of cell proliferation
 Prc1 ELISA Kit
 Prc1 Recombinant
 Prc1 Antibody
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