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Protein scribble

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

Below are the list of possible Protein scribble products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Protein scribble homolog

 Protein scribble homolog ELISA Kit
 Protein scribble homolog Recombinant
 Protein scribble homolog Antibody
Also known as Protein scribble homolog (Scribble) (hScrib) (Protein LAP4).
Scribble: may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of relea
se. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cell junction; cell-cell adherens junction; cytoplasm; intercellular junction; leading edge; nucleoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane

Molecular Function: protein binding

Biological Process: cell migration; cell proliferation; cell-cell adhesion; establishment of apical/basal cell polarity; negative regulation of mitotic cell cycle; neural tube closure; positive chemotaxis; positive regulation of apoptosis; positive regulation of receptor recycling
 SCRIB Recombinant
 SCRIB Antibody
 CRIB1 Recombinant
 CRIB1 Antibody
 KIAA0147 Recombinant
 KIAA0147 Antibody
 LAP4 Recombinant
 LAP4 Antibody
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