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Protein Spindly

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Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).

Below are the list of possible Protein Spindly products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Protein Spindly

 Protein Spindly ELISA Kit
 Protein Spindly Recombinant
 Protein Spindly Antibody
Also known as Protein Spindly (Coiled-coil domain-containing protein 99) (Spindle apparatus coiled-coil domain-containing protein 1).
CCDC99: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore
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-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Belongs to the Spindly family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: nucleus; outer kinetochore of condensed chromosome; spindle pole

Molecular Function: enzyme binding; kinetochore binding

Biological Process: establishment of mitotic spindle orientation; mitotic metaphase plate congression
 Spdl1 ELISA Kit
 Spdl1 Recombinant
 Spdl1 Antibody
 Ccdc99 ELISA Kit
 Ccdc99 Recombinant
 Ccdc99 Antibody
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Protein Spindly-A

 Protein Spindly-A ELISA Kit
 Protein Spindly-A Recombinant
 Protein Spindly-A Antibody
Also known as Protein Spindly-A (Coiled-coil domain-containing protein 99-A) (Spindle apparatus coiled-coil domain-containing protein 1-A).
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-m
>>>
icrotubule attachments mediated by the NDC80 complex.
 spdl1-a ELISA Kit
 spdl1-a Recombinant
 spdl1-a Antibody
 ccdc99-a ELISA Kit
 ccdc99-a Recombinant
 ccdc99-a Antibody
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Protein Spindly-B

 Protein Spindly-B ELISA Kit
 Protein Spindly-B Recombinant
 Protein Spindly-B Antibody
Also known as Protein Spindly-B (Coiled-coil domain-containing protein 99-B) (Spindle apparatus coiled-coil domain-containing protein 1-B).
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-m
>>>
icrotubule attachments mediated by the NDC80 complex.
 spdl1-b ELISA Kit
 spdl1-b Recombinant
 spdl1-b Antibody
 ccdc99-b ELISA Kit
 ccdc99-b Recombinant
 ccdc99-b Antibody
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Proteins Root Name Listing
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