| Queuine tRNA-ribosyltransferase ELISA Kit|
Queuine tRNA-ribosyltransferase Recombinant
Queuine tRNA-ribosyltransferase Antibody
|Also known as Queuine tRNA-ribosyltransferase (Guanine insertion enzyme) (tRNA-guanine transglycosylase). |
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleop
hile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
| tgt ELISA Kit|
| AB57_3415 ELISA Kit|