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Queuine tRNA-ribosyltransferase

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Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Below are the list of possible Queuine tRNA-ribosyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Queuine tRNA-ribosyltransferase

 Queuine tRNA-ribosyltransferase ELISA Kit
 Queuine tRNA-ribosyltransferase Recombinant
 Queuine tRNA-ribosyltransferase Antibody
Also known as Queuine tRNA-ribosyltransferase (Guanine insertion enzyme) (tRNA-guanine transglycosylase).
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleop
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hile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
 tgt ELISA Kit
 tgt Recombinant
 tgt Antibody
 AB57_3415 ELISA Kit
 AB57_3415 Recombinant
 AB57_3415 Antibody
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Queuine tRNA-ribosyltransferase catalytic subunit

 Queuine tRNA-ribosyltransferase catalytic subunit ELISA Kit
 Queuine tRNA-ribosyltransferase catalytic subunit Recombinant
 Queuine tRNA-ribosyltransferase catalytic subunit Antibody
Also known as Queuine tRNA-ribosyltransferase catalytic subunit (Guanine insertion enzyme) (tRNA-guanine transglycosylase).
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified
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nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
 tgt-1 ELISA Kit
 tgt-1 Recombinant
 tgt-1 Antibody
 ZK829.6 ELISA Kit
 ZK829.6 Recombinant
 ZK829.6 Antibody
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Queuine tRNA-ribosyltransferase catalytic subunit 1

 Queuine tRNA-ribosyltransferase catalytic subunit 1 ELISA Kit
 Queuine tRNA-ribosyltransferase catalytic subunit 1 Recombinant
 Queuine tRNA-ribosyltransferase catalytic subunit 1 Antibody
Also known as Queuine tRNA-ribosyltransferase catalytic subunit 1 (Guanine insertion enzyme) (tRNA-guanine transglycosylase).
QTRT1: Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). Belongs to the queuine tRNA-ribosyltransferase family.

Protein type: EC 2.4.2.29; Mitochondrial; RNA processing; T
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ransferase

Cellular Component: cytoplasm; mitochondrion; nucleus

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; queuine tRNA-ribosyltransferase activity

Biological Process: queuosine biosynthetic process
 Qtrt1 ELISA Kit
 Qtrt1 Recombinant
 Qtrt1 Antibody
 Tgt ELISA Kit
 Tgt Recombinant
 Tgt Antibody
 Tgut ELISA Kit
 Tgut Recombinant
 Tgut Antibody
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