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RAC-gamma serine/threonine-protein kinase

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AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis (By similarity).

Below are the list of possible RAC-gamma serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

RAC-gamma serine/threonine-protein kinase

 RAC-gamma serine/threonine-protein kinase ELISA Kit
 RAC-gamma serine/threonine-protein kinase Recombinant
 RAC-gamma serine/threonine-protein kinase Antibody
Also known as RAC-gamma serine/threonine-protein kinase (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma).
Akt3: an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Stimulated by platelet-derived growth factor, insulin, and insulin-like growth factor 1. Alternatively spliced isoforms have been described.

Protein ty
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pe: AGC group; AKT family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular; nucleoplasm; plasma membrane

Molecular Function: ATP binding; protein kinase C binding; protein serine/threonine kinase activity

Biological Process: brain morphogenesis; cellular response to insulin stimulus; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell size; positive regulation of TOR signaling pathway; protein amino acid phosphorylation; signal transduction
 Akt3 ELISA Kit
 Akt3 Recombinant
 Akt3 Antibody
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