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RAC serine/threonine-protein kinase

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Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex. Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth.

Below are the list of possible RAC serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

RAC serine/threonine-protein kinase

 RAC serine/threonine-protein kinase ELISA Kit
 RAC serine/threonine-protein kinase Recombinant
 RAC serine/threonine-protein kinase Antibody
Also known as RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (Akt) (Protein kinase B) (PKB).
Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the
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mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.

Protein type: AGC group; AKT family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: cell soma; cell surface; cytoplasm

Molecular Function: protein kinase activity; protein serine/threonine kinase activity

Biological Process: chitin-based embryonic cuticle biosynthetic process; cholesterol homeostasis; circadian rhythm; dendrite regeneration; epithelial cell migration, open tracheal system; insulin receptor signaling pathway; lipid metabolic process; multicellular organism growth; myoblast fusion; negative regulation of apoptosis; negative regulation of synaptic growth at neuromuscular junction; oogenesis; open tracheal system development; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; protein amino acid phosphorylation; regulation of cell shape; regulation of dendrite development; regulation of hemocyte proliferation; regulation of multicellular organism growth; regulation of protein import into nucleus; response to oxidative stress; sequestering of lipid; somatic muscle development
 Akt1 ELISA Kit
 Akt1 Recombinant
 Akt1 Antibody
 CG4006 ELISA Kit
 CG4006 Recombinant
 CG4006 Antibody
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