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RAF proto-oncogene serine/threonine-protein kinase

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Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).

Below are the list of possible RAF proto-oncogene serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

RAF proto-oncogene serine/threonine-protein kinase

 RAF proto-oncogene serine/threonine-protein kinase ELISA Kit
 RAF proto-oncogene serine/threonine-protein kinase Recombinant
 RAF proto-oncogene serine/threonine-protein kinase Antibody
Also known as RAF proto-oncogene serine/threonine-protein kinase (C-MIL) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (RAF-1).
RAF1: a proto-oncogenic TKL kinase of the RAF family. Functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate and activate MEK1/2, which in turn phosphorylate and activate E
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RK1/2. Acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MEK1/2) and the extracellular signal-regulated kinases (ERK1/2). RAF1, subsequent to phosphorylation by PAK1, phosphorylates BAD (Bcl2-antagonist of cell death) at S75. Phosphorylates adenylyl cyclases ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2 (cardiac muscle troponin T). Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (ASK1 and MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

Protein type: EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RAF family; TKL group

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding

Biological Process: cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of signal transduction; protein amino acid phosphorylation
 RAF1 ELISA Kit
 RAF1 Recombinant
 RAF1 Antibody
 MIL ELISA Kit
 MIL Recombinant
 MIL Antibody
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