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Ragulator complex protein

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As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity).

Below are the list of possible Ragulator complex protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ragulator complex protein LAMTOR1

 Ragulator complex protein LAMTOR1 ELISA Kit
 Ragulator complex protein LAMTOR1 Recombinant
 Ragulator complex protein LAMTOR1 Antibody
Also known as Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1).
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the
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Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation ().
 LAMTOR1 ELISA Kit
 LAMTOR1 Recombinant
 LAMTOR1 Antibody
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Ragulator complex protein LAMTOR2

 Ragulator complex protein LAMTOR2 ELISA Kit
 Ragulator complex protein LAMTOR2 Recombinant
 Ragulator complex protein LAMTOR2 Antibody
Also known as Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3).
LAMTOR2: Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting pr
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otein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: endosome membrane; late endosome; lysosomal membrane

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold

Biological Process: cell cycle arrest; cell growth; macroautophagy; MAPKKK cascade; positive regulation of TOR signaling pathway

Disease: Immunodeficiency Due To Defect In Mapbp-interacting Protein
 LAMTOR2 ELISA Kit
 LAMTOR2 Recombinant
 LAMTOR2 Antibody
 MAPBPIP ELISA Kit
 MAPBPIP Recombinant
 MAPBPIP Antibody
 ROBLD3 ELISA Kit
 ROBLD3 Recombinant
 ROBLD3 Antibody
 HSPC003 ELISA Kit
 HSPC003 Recombinant
 HSPC003 Antibody
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Ragulator complex protein LAMTOR2 homolog

 Ragulator complex protein LAMTOR2 homolog ELISA Kit
 Ragulator complex protein LAMTOR2 homolog Recombinant
 Ragulator complex protein LAMTOR2 homolog Antibody
Also known as Ragulator complex protein LAMTOR2 homolog (Late endosomal/lysosomal adapter and MAPK and MTOR activator 1).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids.
 lmtr-2 ELISA Kit
 lmtr-2 Recombinant
 lmtr-2 Antibody
 Y97E10AR.7 ELISA Kit
 Y97E10AR.7 Recombinant
 Y97E10AR.7 Antibody
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Ragulator complex protein LAMTOR2-A

 Ragulator complex protein LAMTOR2-A ELISA Kit
 Ragulator complex protein LAMTOR2-A Recombinant
 Ragulator complex protein LAMTOR2-A Antibody
Also known as Ragulator complex protein LAMTOR2-A (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2-A) (Roadblock domain-containing protein 3).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
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Adapter protein that may regulate the MAP kinase cascade ().
 lamtor2-a ELISA Kit
 lamtor2-a Recombinant
 lamtor2-a Antibody
 robld3 ELISA Kit
 robld3 Recombinant
 robld3 Antibody
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Ragulator complex protein LAMTOR2-B

 Ragulator complex protein LAMTOR2-B ELISA Kit
 Ragulator complex protein LAMTOR2-B Recombinant
 Ragulator complex protein LAMTOR2-B Antibody
Also known as Ragulator complex protein LAMTOR2-B (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2-B) (Roadblock domain-containing protein 3).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex may, activate the TOR signaling cascade in response to amino acids.
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Adapter protein that may regulate the MAP kinase cascade ().
 lamtor2-b ELISA Kit
 lamtor2-b Recombinant
 lamtor2-b Antibody
 robld3 ELISA Kit
 robld3 Recombinant
 robld3 Antibody
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Ragulator complex protein LAMTOR3

 Ragulator complex protein LAMTOR3 ELISA Kit
 Ragulator complex protein LAMTOR3 Recombinant
 Ragulator complex protein LAMTOR3 Antibody
Also known as Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP k
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inase cascade ().
 lamtor3 ELISA Kit
 lamtor3 Recombinant
 lamtor3 Antibody
 GSTENG00013453001 ELISA Kit
 GSTENG00013453001 Recombinant
 GSTENG00013453001 Antibody
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Ragulator complex protein LAMTOR3 homolog

 Ragulator complex protein LAMTOR3 homolog ELISA Kit
 Ragulator complex protein LAMTOR3 homolog Recombinant
 Ragulator complex protein LAMTOR3 homolog Antibody
Also known as Ragulator complex protein LAMTOR3 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
 CG5110 ELISA Kit
 CG5110 Recombinant
 CG5110 Antibody
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Ragulator complex protein LAMTOR3-A

 Ragulator complex protein LAMTOR3-A ELISA Kit
 Ragulator complex protein LAMTOR3-A Recombinant
 Ragulator complex protein LAMTOR3-A Antibody
Also known as Ragulator complex protein LAMTOR3-A (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-A) (Mitogen-activated protein kinase scaffold protein 1).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response t
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o amino acids. Adapter protein that may regulate the MAP kinase cascade ().
 lamtor3-a ELISA Kit
 lamtor3-a Recombinant
 lamtor3-a Antibody
 mapksp1 ELISA Kit
 mapksp1 Recombinant
 mapksp1 Antibody
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Ragulator complex protein LAMTOR3-B

 Ragulator complex protein LAMTOR3-B ELISA Kit
 Ragulator complex protein LAMTOR3-B Recombinant
 Ragulator complex protein LAMTOR3-B Antibody
Also known as Ragulator complex protein LAMTOR3-B (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-B) (Mitogen-activated protein kinase scaffold protein 1).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response t
>>>
o amino acids. Adapter protein that may regulate the MAP kinase cascade ().
 lamtor3-b ELISA Kit
 lamtor3-b Recombinant
 lamtor3-b Antibody
 mapksp1 ELISA Kit
 mapksp1 Recombinant
 mapksp1 Antibody
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Ragulator complex protein LAMTOR4

 Ragulator complex protein LAMTOR4 ELISA Kit
 Ragulator complex protein LAMTOR4 Recombinant
 Ragulator complex protein LAMTOR4 Antibody
Also known as Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids ().
 lamtor4 ELISA Kit
 lamtor4 Recombinant
 lamtor4 Antibody
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Ragulator complex protein LAMTOR4 homolog

 Ragulator complex protein LAMTOR4 homolog ELISA Kit
 Ragulator complex protein LAMTOR4 homolog Recombinant
 Ragulator complex protein LAMTOR4 homolog Antibody
Also known as Ragulator complex protein LAMTOR4 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids ().
 v1g232793 ELISA Kit
 v1g232793 Recombinant
 v1g232793 Antibody
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Ragulator complex protein LAMTOR5

 Ragulator complex protein LAMTOR5 ELISA Kit
 Ragulator complex protein LAMTOR5 Recombinant
 Ragulator complex protein LAMTOR5 Antibody
Also known as Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5).
HBXIP: When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. Belongs to the HBXIP family.

Protein type: Apoptosis; DNA replication

Chromosomal Location of
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Human Ortholog: 1p13.3

Cellular Component: cytosol; lysosomal membrane; lysosome

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold

Biological Process: cell cycle arrest; macroautophagy; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of TOR signaling pathway; regulation of cell size; response to virus
 LAMTOR5 ELISA Kit
 LAMTOR5 Recombinant
 LAMTOR5 Antibody
 HBXIP ELISA Kit
 HBXIP Recombinant
 HBXIP Antibody
 XIP ELISA Kit
 XIP Recombinant
 XIP Antibody
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Ragulator complex protein LAMTOR5 homolog

 Ragulator complex protein LAMTOR5 homolog ELISA Kit
 Ragulator complex protein LAMTOR5 homolog Recombinant
 Ragulator complex protein LAMTOR5 homolog Antibody
Also known as Ragulator complex protein LAMTOR5 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5).
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids ().
 v1g226489 ELISA Kit
 v1g226489 Recombinant
 v1g226489 Antibody
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