| RalBP1-associated Eps domain-containing protein 2 ELISA Kit|
RalBP1-associated Eps domain-containing protein 2 Recombinant
RalBP1-associated Eps domain-containing protein 2 Antibody
|Also known as RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2). |
REPS2: an adaptor protein involved in growth factor signaling through its influence on the Ral, a small G protein that regulates endocytosis of EGF and insulin receptors. Interacts with DDEF1, paxillin, RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of
the latter. Forms a ternary complex with activated Ral and RALBP1. Binds epsin 1. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. EGF receptor internalization and signalling is inhibited by increased expression of REPS2. EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2. Two alternatively spliced isoforms have been described. Isoform 2 is down-regulated during progression of prostate cancer.
Protein type: Adaptor/scaffold; G protein regulator, misc.
Chromosomal Location of Human Ortholog: Xp22.2
Molecular Function: protein binding
Biological Process: epidermal growth factor receptor signaling pathway; protein complex assembly
| REPS2 ELISA Kit|
| POB1 ELISA Kit|