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Rap guanine nucleotide exchange factor

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Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle.

Below are the list of possible Rap guanine nucleotide exchange factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Rap guanine nucleotide exchange factor

 Rap guanine nucleotide exchange factor ELISA Kit
 Rap guanine nucleotide exchange factor Recombinant
 Rap guanine nucleotide exchange factor Antibody
Also known as Rap guanine nucleotide exchange factor (RA-GEF) (PDZ-domain-containing exchange factor).
Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle.
 pxf-1 ELISA Kit
 pxf-1 Recombinant
 pxf-1 Antibody
 ra-gef ELISA Kit
 ra-gef Recombinant
 ra-gef Antibody
 T14G10.2 ELISA Kit
 T14G10.2 Recombinant
 T14G10.2 Antibody
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Rap guanine nucleotide exchange factor 1

 Rap guanine nucleotide exchange factor 1 ELISA Kit
 Rap guanine nucleotide exchange factor 1 Recombinant
 Rap guanine nucleotide exchange factor 1 Antibody
Also known as Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G).
RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.

Protein type: GE
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Fs; GEFs, Ras; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytosol; early endosome; endosome

Molecular Function: protein binding; Rap guanyl-nucleotide exchange factor activity

Biological Process: activation of MAPKK activity; positive regulation of GTPase activity; Rap protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
 RAPGEF1 ELISA Kit
 RAPGEF1 Recombinant
 RAPGEF1 Antibody
 GRF2 ELISA Kit
 GRF2 Recombinant
 GRF2 Antibody
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Rap guanine nucleotide exchange factor 2

 Rap guanine nucleotide exchange factor 2 ELISA Kit
 Rap guanine nucleotide exchange factor 2 Recombinant
 Rap guanine nucleotide exchange factor 2 Antibody
Also known as Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1).
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct associa
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tion with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions (). Binds to cAMP.
 RAPGEF2 ELISA Kit
 RAPGEF2 Recombinant
 RAPGEF2 Antibody
 NRAPGEP ELISA Kit
 NRAPGEP Recombinant
 NRAPGEP Antibody
 PDZGEF1 ELISA Kit
 PDZGEF1 Recombinant
 PDZGEF1 Antibody
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Rap guanine nucleotide exchange factor 3

 Rap guanine nucleotide exchange factor 3 ELISA Kit
 Rap guanine nucleotide exchange factor 3 Recombinant
 Rap guanine nucleotide exchange factor 3 Antibody
Also known as Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI).
Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, misc.

Cellular Component: apical part of cell;
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basal plasma membrane; brush border membrane; cell soma; cortical actin cytoskeleton; filopodium; growth cone; lamellipodium; microvillus; nerve terminal; perinuclear region of cytoplasm; plasma membrane

Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity

Biological Process: negative regulation of collagen biosynthetic process; positive regulation of angiogenesis; positive regulation of cell size; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; Rap protein signal transduction
 Rapgef3 ELISA Kit
 Rapgef3 Recombinant
 Rapgef3 Antibody
 Epac ELISA Kit
 Epac Recombinant
 Epac Antibody
 Epac1 ELISA Kit
 Epac1 Recombinant
 Epac1 Antibody
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Rap guanine nucleotide exchange factor 4

 Rap guanine nucleotide exchange factor 4 ELISA Kit
 Rap guanine nucleotide exchange factor 4 Recombinant
 Rap guanine nucleotide exchange factor 4 Antibody
Also known as Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII).
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2
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and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: GEFs; GEFs, Ras

Cellular Component: apical plasma membrane; axon; basolateral plasma membrane; brush border; cell soma; cilium; cytosol; dendrite; dendritic spine; excitatory synapse; growth cone; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; protein complex

Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: calcium ion-dependent exocytosis; cAMP-mediated signaling; insulin secretion; negative regulation of synaptic transmission; positive regulation of protein secretion; positive regulation of smooth muscle cell migration; regulation of dendrite development; regulation of exocytosis; signal transduction
 Rapgef4 ELISA Kit
 Rapgef4 Recombinant
 Rapgef4 Antibody
 Cgef2 ELISA Kit
 Cgef2 Recombinant
 Cgef2 Antibody
 Epac2 ELISA Kit
 Epac2 Recombinant
 Epac2 Antibody
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Rap guanine nucleotide exchange factor 5

 Rap guanine nucleotide exchange factor 5 ELISA Kit
 Rap guanine nucleotide exchange factor 5 Recombinant
 Rap guanine nucleotide exchange factor 5 Antibody
Also known as Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).
RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras

Cellular Component: nucleus

Molecular Function: GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity
 Rapgef5 ELISA Kit
 Rapgef5 Recombinant
 Rapgef5 Antibody
 Gfr ELISA Kit
 Gfr Recombinant
 Gfr Antibody
 Kiaa0277 ELISA Kit
 Kiaa0277 Recombinant
 Kiaa0277 Antibody
 Mrgef ELISA Kit
 Mrgef Recombinant
 Mrgef Antibody
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Rap guanine nucleotide exchange factor 6

 Rap guanine nucleotide exchange factor 6 ELISA Kit
 Rap guanine nucleotide exchange factor 6 Recombinant
 Rap guanine nucleotide exchange factor 6 Antibody
Also known as Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).
RAPGEF6: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Ras

Chromosomal Location of Human
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Ortholog: 5q31.1

Cellular Component: apical plasma membrane; cytosol; endocytic vesicle; plasma membrane

Molecular Function: GTP-dependent protein binding; guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding

Biological Process: microvillus biogenesis; positive regulation of GTPase activity
 RAPGEF6 ELISA Kit
 RAPGEF6 Recombinant
 RAPGEF6 Antibody
 PDZGEF2 ELISA Kit
 PDZGEF2 Recombinant
 PDZGEF2 Antibody
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Rap guanine nucleotide exchange factor-like 1

 Rap guanine nucleotide exchange factor-like 1 ELISA Kit
 Rap guanine nucleotide exchange factor-like 1 Recombinant
 Rap guanine nucleotide exchange factor-like 1 Antibody
Probable guanine nucleotide exchange factor (GEF).
 RAPGEFL1 ELISA Kit
 RAPGEFL1 Recombinant
 RAPGEFL1 Antibody
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